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Speaker: Rana Zeine, MD, PhD
Research Assistant Professor
Northwestern University
Feinberg School of Medicine
RH Lurie Comprehensive Cancer Center
Chicago, Illinois
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Topic:
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"Significance of Vascular Endothelial Proliferation in
Neuroblastoma and Anti-Angiogenic Treatment" |
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The International Neuroblastoma Pathology Committee classifies tumors into 7 types categorized as either
Schwannian stroma (SS)-poor, -rich, or-dominant. Clinical risk group designations are based on age, MKI,
MYCN amplification, ploidy, chromosomal aberrations and stage. To investigate the relation between tumor
behavior, histopathology and angiogenesis we evaluated vascular morphology on H&E, CD31, vWF and alpha-
SMA stained sections from over 200 cases. We found that Vascular Endothelial Proliferation (VEP) was
present only in SS-poor tumors and regions, and was associated with shorter survival and other high risk
factors. We evaluated neuroblastoma xenografts following in vivo treatment with Thrombospondin-1 peptides
and/or Valproic acid. Anti-angiogenic treatment abrogated VEP. Our observations describe the histologic
counterpart for ‘normalization’ of vessels seen in dynamic leakage studies. Our results suggest that
histopathologic evaluation of Neuroblastoma for VEP could refine risk group designation, modify eligibility
criteria for clinical trials, and provide insight on tumor response to anti-angiogenic therapy.
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When:
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Monday, October 23, 2006
12:00PM – 1:00PM
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Location:
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Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor |
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Selected Recent References for Rana Zeine, MD, PhD
ZEINE, R., Cammer, W., Barbarese, E., Liu, C.-C., Raine, C.S. Structural
dynamics of oligodendrocyte lysis by perforin in culture: Relevance to
Multiple Sclerosis. J. Neuroscience Research 2001, 64(4):380-391.
ZEINE, R., Pon, R., Ladiwala, U., Antel, J.P., Filion, L. and Freedman, M.S.
Mechanism of T cell-induced human oligodendrocyte cytotoxicity: Relevance to Multiple Sclerosis. J. Neuroimmunology 1998, 87:49-61.
Renno, T., ZEINE, R., Girard, J.M., Gillani, S., Dodelet, V. and Owens, T. Selective enrichment of Th1 CD45RBlow CD4+ T cells in autoimmune infiltrates in Experimental Allergic Encephalomyelitis. J. International Immunology 1994, 6:347-354
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ZEINE, R. and Owens, T. Loss rather than downregulation of CD4+ T cells
as a mechanism for remission from Experimental Allergic Encepha-lomyelitis. J. Neuroimmunology 1993, 44:193-198.
ZEINE, R., Heath, D. and Owens, T. Enhanced responses to antigens within lymph nodes of SJL/J mice that were protected against Experimental Allergic Encephalomyelitis by T-cell-vaccination. J. Neuroimmunology 1993, 44:85-94.
ZEINE, R., and Owens, T. Direct demonstration of the infiltration of murine CNS
by Pgp-1/ CD44high CD45RBlow CD4+ T cells that induce Experimental Allergic Encephalomyelitis. J. Neuroimmunology 1992, 40:57-70.
Owens, T. and ZEINE, R. The cell biology of T-dependent B cell activation.
Biochem. Cell. Biol. 1989, 67: 481-489.. |
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