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Speaker: Isabelle Coppens, PhD
Assistant Professor
Department of Molecular Microbiology and Immunology
John Hopkins Bloomberg School of Public Health
website: http://faculty.jhsph.edu/Default.cfm?faculty_id=447
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Topic:
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"Manipulating cellular transport processes: Dynamic interaction between intracellular toxoplasma and its host cell" |
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Toxoplasma gondii is unarguably one of the most successful intracellular pathogens of medical importance. This parasite multiplies within a unique parasitophorous vacuole that provides a balance between the parasite's anabolic needs and the subversion of host defenses. We demonstrate that Toxoplasma is able to craftily redirect host organelles to the parasitophorous vacuole in order to divert nutrients from them and/or to interfere with host immunity. Through the exploitation of host endocytic structures, the parasite gains access to diverse nutrients from host digestive compartments sequestered in the vacuole. The parasite hijacks the host microtubule-organizing center and maintains a tight association with this structure throughout the course of infection, which causes irreversible centrosomal defects. The ensuing alteration of the host microtubular network and fragmentation of the Golgi apparatus in infected cells lead to an arrest in host cell division and an impairment of secretion. Jointly these observations outline some virulence strategies developed by Toxoplasma to transform the extreme environment of a cell interior into a replication-permissive habitat.
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When:
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Monday, November 6, 2006
12:15PM – 1:15PM
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Location:
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Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor |
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Selected Recent References for Isabelle Coppens, PhD
Pisciotta JM, Coppens I, Tripathi AK, Scholl PF, Shuman J, Bajad S, Shulaev V, Sullivan DJ. The role of neutral lipid nanospheres in Plasmodium falciparum heme crystallization. Biochem J. 2006 Oct 17; [Epub ahead of print].
Ling YM, Shaw MH, Ayala C, Coppens I, Taylor GA, Ferguson DJ, Yap GS. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med. 2006 Sep 4;203(9):2063-71. Epub 2006 Aug 28.
Harper JM, Huynh MH, Coppens I, Parussini F, Moreno S, Carruthers VB. A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex. Mol Biol Cell. 2006 Oct;17(10):4551-63. Epub 2006 Aug 16.
Coppens I., Dunn J.D., Romano J.D., Pypaert M., Zhang H., Boothroyd J.C. and Joiner K.A. Toxoplasma gondii Sequesters Lysosomes from Mammalian Hosts in the Vacuolar Space. Cell 2006. 125, 261-274.
Sehgal A., Bettiol S., Pypaert M., Wenk M.R., Kaasch A., Blader I.J., Joiner K.A. and Coppens I. Peculiarities of host cholesterol transport to the unique intracellular vacuole containing Toxoplasma.Traffic 2005. 6, 1125-1141.
Nishikawa Y., Quittnat F., Stedman T.T., Voelker D.R., Choi J.Y., Zahn M., Yang M., Pypaert M., Joiner K.A. and Coppens I. Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma. Cell Microbiol. 2005. 7, 849-867.
Coppens I. and Vielemeyer O. Insights into unique physiological features of neutral lipids in Apicomplexa: from storage to potential mediation in parasite metabolic activities. Int. J. Parasitol. 2005. 35, 597-615.
Gupta N., Zahn M.M., Coppens I., Joiner K.A., Voelker D.R. Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. J. Biol. Chem. 2005. 280, 16345-16353.
Quittnat F., Nishikawa Y., Stedman T.T., Voelker D.R., Choi J.Y., Zahn M.M., Murphy R.C., Barkley R.M., Pypaert M., Joiner K.A. and Coppens I. On the biogenesis of lipid bodies in ancient eukaryotes: synthesis of triacylglycerols by a Toxoplasma DGAT1-related enzyme. Mol. Biochem. Parasitol. 2004. 138, 107-122.
Yang M., Coppens I., Wormsley S., Baevova P., Hoppe H.C. and Joiner K.A. The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation. J. Cell Sci. 2004. 117, 3831-3838.
Vielemeyer O., McIntosh M.T., Joiner, K.A. and Coppens I. Neutral lipid synthesis and storage in the intraerythrocytic stages of Plasmodium falciparum. Mol. Biochem. Parasitol. 2004. 135, 197-209.
 View more Publications by Isabelle Coppens, PhD
listed in the National Library of Medicine (PubMed) |
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