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Speaker: Magali Fontaine, MD, PhD
Assistant Professor of Pathology
and Associate Director of Transfusion Services
Stanford University School of Medicine
Stanford, California
website: http://med.stanford.edu/profiles/pathology/frdActionServlet?choiceId=facProfile&fid=6014
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Topic:
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"Preservation of pancreatic islet cell mass for transplantation in Type 1 Diabetes" |
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At the frontier of transfusion medicine and whole organ transplantation, the emerging field of cellular therapy has become an alternative therapeutic modality for diseases such as type 1 diabetes using islet cells of Langerhans transplantation. Insulin-dependent type 1 diabetes can now be successfully reversed by transplanting pancreatic islets of Langerhans into the portal venous tract of the liver where islets sustain insulinproduction. Even though the process of islet isolation has greatly improved and is now performed across the United States at various transplant centers, the success of islet transplantation remains limited. Our laboratory focuses first on improving viability and function of islets isolated from cadaveric donors, second on
proliferation and expansion of islet cell mass in vitro and lastly on standardized assays to monitor islet viability, function, and tolerogenicity both in vitro and in vivo prior to transplantation.
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When:
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Monday, November 20, 2006
12:00PM – 1:00PM
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Location:
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Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
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Selected Recent References for Magali Fontaine, MD, PhD
Fontaine MJ, Malone J, Mullins FM, Grumet FC "Diagnosis of Transfusion-Related Acute Lung Injury: TRALI or Not TRALI?" Ann Clin Lab Sci 2006; 36: 1: 53-8.
Fontaine MJ, Lazarchick J, Taylor S, Annibale D "Use of recombinant factor VIIa in infants with severe coagulopathy." J Perinatol 2004; 24: 5: 310-1.
Marques RG, Fontaine MJ, Rogers J., "C-peptide: much more than a byproduct of insulin biosynthesis." Pancreas 2004; 29: 3: 231
Fontaine MJ, Fan W "Islet cell transplantation as a cure for insulin dependent diabetes: current improvements in preserving islet cell mass and function." Hepatobiliary Pancreat Dis Int 2003; 2: 2: 170-9.
Fontaine MJ, Winters JL, Moore SB, McGregor CG, Santrach PJ "Frozen preoperative autologous blood donation for heart transplantation at the Mayo Clinic from 1988 to 1999." Transfusion 2003; 43: 4: 476-80.
Fontaine MJ, Blanchard J, Rastellini C, Lazda V, Herold KC, Pollak R. Pancreatic islets activate portal vein endothelial cells in vitro. Ann Clin Lab Sci. 2002 Fall;32(4):352-61.
Raofi V, Holman DM, Dunn TB, Fontaine MJ, Mihalov MM, Vitello JM, Asolati M, Benedetti E. Comparison of rejection rate and functional outcome of small bowel transplantation alone or in conjunction with the ileocecal valve versus combined small and large bowel transplantation. Clin Transplant. 1999 Oct;13(5):389-94.
Raofi V, Fontaine MJ, Mihalov ML, Holman DM, Dunn TB, Vitello JM, Asolati M, Kumins NH, Benedetti E. Comparison of jejunal and ileal surveillance biopsies in a porcine model of intestinal transplantation. Transplantation. 1999 Jul 27;68(2):188-91.
 View more Publications by Magali Fontaine, MD, PhD
listed in the National Library of Medicine (PubMed) |
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