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Speaker: Gregory R. Dressler, PhD
Associate Professor
Department of Pathology
University of Michigan
Ann Arbor, Michigan
website: http://www.pathology.med.umich.edu/faculty/Dressler/index.html
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Topic:
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"Epithelial-Mesenchymal Transitions in Kidney Development and Disease" |
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Most of the progenitor cells of the nephron are mesenchymal in origin but are induced to polarize and convert into epithelia. This induction is mediated by Wnt signaling and the Pax2 transcription factor. Pax2 is essential for responding to inductive signals and specifies the renal epithelial cell lineage. We can now show that Pax interacts with a histone methyltransferase complex such that renal specific genes are epigentically marked. In adult kidneys however, the transition from epithelia-to-mesenchyme (EMT) may be reversed in certain disease states. The BMP and TGF-b signaling pathways have been implicated in renal fibrotic disease, which is thought to be due at least in part to EMT. We have identified a modifier of the BMP and TGF-b pathway which can regulate susceptibility to renal injury. Thus, the establishment and maintenance of the epithelial phenotype requires a delicate balance between intrinsic and extrinsic factors.
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When:
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Monday, December 11, 2006
12:00PM – 1:00PM
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Location:
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Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
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Selected Recent References for Gregory R. Dressler, PhD
Clarke JC, Patel SR, Raymond RM Jr, Andrew S, Robinson BG, Dressler GR, Brophy PD. Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum Mol Genet. 2006 Dec 1;15(23):3420-8. Epub 2006 Oct 17..
Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28. Epub 2006 Oct 12..
Dressler GR. The cellular basis of kidney development. Annu Rev Cell Dev Biol. 2006;22:509-29..
Lin J, Patel SR, Wang M, Dressler GR. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Mol Cell Biol. 2006 Jun;26(12):4577-85..
Dressler GR. Proposed changes to biomedical funding. Science. 2005 Nov 25;310(5752):1279..
Kim D, Dressler GR. Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J Am Soc Nephrol. 2005 Dec;16(12):3527-34. Epub 2005 Nov 2.
Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med. 2005 Nov;11(11):512-8. Epub 2005 Oct 10..
Lin J, Patel SR, Cheng X, Cho EA, Levitan I, Ullenbruch M, Phan SH, Park JM, Dressler GR. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 2005 Apr;11(4):387-93. Epub 2005 Mar 27..
 View more Publications by Gregory R. Dressler, PhD
listed in the National Library of Medicine (PubMed) |
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