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Speaker: Michael P. Sarras Jr., PhD
Vice President for Research and Dean of
The School of Graduate and Postdoctoral Studies
Professor of Cell Biology and Anatomy
Rosalind Franklin University of Medicine and Science
North Chicago, Illinois
website: http://www.rosalindfranklin.edu/administration/sarras.cfm
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Topic:
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"The Interplay of Cell/Extracellular Matrix Interactions and Metalloproteinases during Morphogenesis and Tissue Regeneration" |
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There is a great deal of interest to study the role of cell/extracellular matrix (ECM) interactions in regeneration of epithelial and connective tissue systems during various processes, including neoplasia, angiogenesis and embryonic development. Our laboratory has utilized the Hydra and Zebrafish as models to study various events during morphogenesis and regeneration. The Hydra is a simpler structure (an epithelial bilayer composed of an ectoderm and endoderm with an intervening ECM) and has a high regenerative capacity with the formation and organization of dissociated cells into adult hydra within 72 hours. Our studies indicate that these developmental processes are intimately tied to signaling between the epithelial bilayer, ECM biogenesis and the interplay of ECM components and metalloproteinases (MMP). Using genetic approaches, our laboratory investigated the role of membrane-bound MMPs (MT-MMP) in early development and regeneration in Zebrafish model. A high expression of MMPs in Zebrafish fins (a connective tissue structure) and a vital role of MT1-MMP in their development was elucidated. Currently by the use of reverse genetic analysis we are trying to determine the mechanisms underlying the role of MMPs in fin regeneration.
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When:
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Monday, January 15, 2007
12:00PM – 1:00PM
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Location:
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Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
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Selected Recent References for Michael P. Sarras Jr., PhD
Zhang X, Boot-Handford RP, Huxley-Jones J, Forse LN, Mould AP, Robertson DL, Li L, Athiyal M, Sarras MP Jr. The collagens of hydra provide insight into the evolution of metazoan extracellular matrices. J Biol Chem. 2007 Jan 3.
Thummel R, Bai S, Sarras MP Jr, Song P, McDermott J, Brewer J, Perry M, Zhang X, Hyde DR, Godwin AR. Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Dev Dyn. 2006 Feb;235(2):336-46.
Thummel R, Burket CT, Brewer JL, Sarras MP Jr, Li L, Perry M, McDermott JP, Sauer B, Hyde DR, Godwin AR. Cre-mediated site-specific recombination in zebrafish embryos. Dev Dyn. 2005 Aug;233(4):1366-77.
Bai S, Thummel R, Godwin AR, Nagase H, Itoh Y, Li L, Evans R, McDermott J, Seiki M, Sarras MP Jr. Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix Biol. 2005 Jun;24(4):247-60.
Thummel R, Li L, Tanase C, Sarras MP Jr, Godwin AR. Differences in expression pattern and function between zebrafish hoxc13 orthologs: recruitment of Hoxc13b into an early embryonic role. Dev Biol. 2004 Oct 15;274(2):318-33.
Zhang J, Bai S, Zhang X, Nagase H, Sarras MP Jr. The expression of gelatinase A (MMP-2) is required for normal development of zebrafish embryos. Dev Genes Evol. 2003 Sep;213(9):456-63. Epub 2003 Jul 29.
Paunesku T, Zhang Y, Gemmell MA, Woloschak GE. p53 gene deletions in paraffin-preserved lymphoid tumors from irradiated mice. Leuk Res. 2000 Jun;24(6):511-7.
 View more Publications by Michael P. Sarras Jr., PhD
listed in the National Library of Medicine (PubMed) |
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