Speaker: Pierre D. McCrea, PhD

Topic:

"Not just beta-catenin anymore: the p120-catenin in Wnt developmental signaling"

When:

Monday, January 22, 2007
12:00PM – 1:00PM
 

Location:

Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
  

Hosted by Dr. Anjen Chenn, MD, PhD

Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD.  Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals.  Dev Cell. 2006 Nov;11(5):683-95.

McCrea PD, Park JI.  Developmental functions of the P120-catenin sub-family.  Biochim Biophys Acta. 2007 Jan;1773(1):17-33. Epub 2006 Jul 1.

van Roy FM, McCrea PD.  A role for Kaiso-p120ctn complexes in cancer?  Nat Rev Cancer. 2005 Dec;5(12):956-64.

Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD.  Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets.  Dev Cell. 2005 Jun;8(6):843-54. Erratum in: Dev Cell. 2005 Aug;9(2):305..

Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD.  Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.  Nat Cell Biol. 2004 Dec;6(12):1212-20. Epub 2004 Nov 14.

Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR, McCrea PD, de Crombrugghe B.  Interactions between Sox9 and beta-catenin control chondrocyte differentiation.  Genes Dev. 2004 May 1;18(9):1072-87.