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Speaker: Jeffrey E. Saffitz, MD, PhD
Mallinckrodt Professor of Pathology
Harvard Medical School
Chief, Department of Pathology
Beth Israel Deaconess Medical Center
Boston, Massachusetts
website: http://www.bidmc.harvard.edu/display.asp?leaf_id=14437
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Topic:
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"Mechanisms of Sudden Death in the
Cell-Cell Junction Cardiomyopathies" |
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The talk will focus on a group of familial cardiomyopathies caused by mutations in genes encoding proteins at
intercellular adhesion junctions in cardiac myocytes. These cardiomyopathies are associated with contractile dysfunction and a high incidence of ventricular arrhythmias and sudden cardiac death. We have proposed that sudden death in the cell-cell junction cardiomyopathies is related to remodeling of electrical junctions (gap junctions) caused by defects in intercellular adhesion. The seminar will review basic aspects of intercellular coupling at gap junctions in the heart and explore functional relationships between electrical and mechanical coupling in cardiac myocytes. |
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When:
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Monday, January 29, 2007
12:00PM – 1:00PM
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Location:
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Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
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Selected Recent References for Jeffrey E. Saffitz, MD, PhD
Mancuso DJ, Han X, Jenkins CM, Lehman JJ, Sambandam N, Sims HF, Yang J, Yan W, Yang K, Green K, Abendschein DR, Saffitz JE, Gross RW. Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem. 2007 Jan 9.
Beauchamp P, Yamada KA, Baertschi AJ, Green K, Kanter EM, Saffitz JE, Kleber AG. Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes. Circ Res. 2006 Nov 24;99(11):1216-24.
Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 2006 Sep 15;99(6):646-55. Epub 2006 Aug 17.
Saffitz JE. Connexins, conduction, and atrial fibrillation. N Engl J Med. 2006 Jun 22;354(25):2712-4.
Saffitz JE. Adhesion molecules: why they are important to the electrophysiologist. J Cardiovasc Electrophysiol. 2006 Feb;17(2):225-9.
Tang D, Yang C, Zheng J, Woodard PK, Saffitz JE, Sicard GA, Pilgram TK, Yuan C. Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models. J Biomech Eng. 2005 Dec;127(7):1185-94.
 View more Publications by Jeffrey E. Saffitz, MD, PhD
listed in the National Library of Medicine (PubMed) |
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