|
|
|
|
|
 |
| |
Speaker: Scott A. Weed, PhD
Associate Professor
Director, Graduate Program in Cancer Cell Biology
Mary Babb Randolph Cancer Center
West Virginia University
Morgantown, West Virginia
website: http://www.hsc.wvu.edu/mbrcc/research/bios/weed.asp
|
|
|
|
|
| |
Topic:
|
|
"Cytoskeletal Regulation of Tumor Cell Motility and Invasion" |
|
 |
|
|
Dynamic regulation of the actin cytoskeleton is central to cell movement and is regulated by a number of actinbinding proteins. Cortactin is an actin-associated protein that is phosphorylated following activation of numerous receptor and non-receptor tyrosine kinase pathways. Cortactin binds and activates the Arp2/3 complex, contributing to the formation of the cortical dendritic actin network in lamellipodia as well suppressing the metastability of Arp2/3-actin branch points. Cortactin is also a core component of invadopodia, actin-rich ventral protrusions found in carcinoma cells that are responsible for focal degradation of the extracellular matrix. Cortactin is overexpressed in several carcinomas as a result of gene amplification, corresponding with poor patient outcome. This presentation will focus on the role of cortactin in lamellipodia and invadopodia function, the impact of cortactin overexpression on tumor cell motility, and the suitability of cortactin as a prognostic biomarker for small molecule inhibitors of tumor cell invasion and metastasis. |
|
| |
When:
|
|
Monday, February 26, 2007
12:00PM – 1:00PM
|
|
| |
Location:
|
|
Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
|
|
| |
|
|
| |
Selected Recent References for Scott A. Weed, PhD
Greer RO Jr, Said S, Shroyer KR, Marileila VG, Weed SA. Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Oral Oncol. 2006 Nov 16.
Rothschild BL, Shim AH, Ammer AG, Kelley LC, Irby KB, Head JA, Chen L, Varella-Garcia M, Sacks PG, Frederick B, Raben D, Weed SA. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res. 2006 Aug 15;66(16):8017-25.
Gatesman A, Walker VG, Baisden JM, Weed SA, Flynn DC. Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Mol Cell Biol. 2004 Sep;24(17):7578-97.
Bougneres L, Girardin SE, Weed SA, Karginov AV, Olivo-Marin JC, Parsons JT, Sansonetti PJ, Van Nhieu GT. Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells. J Cell Biol. 2004 Jul 19;166(2):225-35.
Fan L, Di Ciano-Oliveira C, Weed SA, Craig AW, Greer PA, Rotstein OD, Kapus A. Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. Biochem J. 2004 Jun 1;380(Pt 2):581-91.
Helwani FM, Kovacs EM, Paterson AD, Verma S, Ali RG, Fanning AS, Weed SA, Yap AS. Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J Cell Biol. 2004 Mar 15;164(6):899-910.
 View more Publications by Scott A. Weed, PhD
listed in the National Library of Medicine (PubMed) |
|
|
|
|
|
|
