Speaker: Angela L. Tyner, Ph.D.

Professor
Department of Biochemistry and Molecular Genetics
University of Illinios College of Medicine
Chicago, IL

website:http://www.uic.edu/com/bcmg/tyner.html
  

Topic:

" The intracellular tyrosine kinase PTK6:
a regulator of growth, differentiation, and cell survival"

PTK6 (also referred to as the breast tumor kinase BRK) is an intracellular tyrosine kinase that is expressed at high levels in approximately 60% of human breast tumors, but it is not expressed in the normal mammary gland. However PTK6 is expressed in normal skin, all epithelial linings of the gastrointestinal tract, and the prostate where it is localized to nondividing differentiated epithelial cells. Functions of PTK6 in epithelial signaling and its roles in regulating renewal of the intestinal epithelium will be discussed. We will also explore how this kinase may have different functions in normal epithelia and in cancer.

When:

Monday, April 9, 2007
12:00PM – 1:00PM
 

Location:

Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
  

Hosted by Dr. Kathy Green, Ph.D

Haegebarth A, Bie W., Yang R., Crawford S. E., Vasiouhkhin V., Fuchs E., and A.L. Tyner. 2006. Protein Tyrosine Kinase 6 Negatively Regulates Growth and Promotes Enterocyte Differentiation in the Small Intestine. Mol. Cell. Biol. 26(13): 4949-4957.

Yang R., Bie W., Haegebarth A., and A. L. Tyner. 2006. Differential regulation of D-type cyclins in the mouse intestine. Cell Cycle 5(2):180-3

Lukong K.E., Larocque D., Tyner A. L., Richard S. 2005. Tyrosine phosphorylation of SAM68 by BRK regulates intranuclear localization and cell cycle progression. J Biol Chem. 280(46):38639-47.

Haegebarth A., Nunez R. and A. L. Tyner. 2005. The Intracellular Tyrosine Kinase Brk Sensitizes Nontransformed Cells to Inducers of Apoptosis. Cell Cycle 4(9):1239-46.

Lim D. Y., Tyner A. L., Park J.B., Lee J. Y., Choi Y. H., and J. H. Park. 2005. Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21(CIP1/WAF1). J Cell Physiol. 205(1):107-13.