Speaker: Anthony Kossiakoff, PhD

Chair and Professor of Biochemistry and Molecular Biology
University of Chicago

website: http://molbio.uchicago.edu/Faculty_and_Research/02_Faculty_by_Graduate_Program/01_Biochemistry_and_Molecular_Biology.php?faculty_id=6

Topic:

“Molecular engineering of new tools for drug delivery and imaging”

When:

Monday, December 10, 2007
12:00PM – 1:00PM
 

Location:

Baldwin Auditorium
Robert H. Lurie Medical Research Center
303 East Superior Street, 1st floor
  

Hosted by Dr. Charels Clevenger

Kouadio, J., Horn, J., Pal, G., Kossiakoff, A. A. (2005) "Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface." J. Biol. Chem. 280(27):3852-6. 

Pal, G., Ultsch, M., Clark, K., Currell, B. Kossiakoff, A. A., Sidhu, S. (2005) "Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis." J. Mol. Biol. 347(3): 489-94 

Gopal, B., Madan, L., Betz, S., Kossiakoff, A. A. (2005) " The crystal structure of a quercetin 2, 3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s)." Biochemistry 44(1): 193-201.

Walsh, S. , Sylvester, J., Kossiakoff, A. A. (2004) "The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled." Proc. Natl. Acad. Sci. U.S.A 101(49): 17078-83.


Pal, G., Kossiakoff, A. A., and Sidhu, S. S. (2003) "The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: Insights into the mechanisms responsible for improved affinity." J. Mol. Biol. 332: 195- 204.