Vinay Kumar, MBBS, MD, FRCPath.

Alice Hogge and Arthur A. Baer Professor
Chairman, Department of Pathology,
The University of Chicago
Executive Vice Dean, Division of Biological Sciences

website: http://biomed.uchicago.edu/common/faculty/kumar.html

Topic:

"Molecular basis of the dual function of CD244 and its impact on the function of natural killer cells"

When:

Monday, January 5, 2009
12:00PM – 1:00PM
 

Location:

Hughes Auditorium, Lurie Building

Bass Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK, Denning M, Green KJ. Plakophilin 2: a critical scaffold for PKC-alpha that regulates intercellular junction assembly. J. Cell Biol. 181: 605-13, 2008

Dusek RL, Godsel LM, Chen F, Strohecker AM, Getsios S, Harmon R, Muller EJ, Caldelari R, Cryns VL, Green KJ. Plakoglobin Deficiency Protects Keratinocytes from Apoptosis. J Invest Dermatol. 127:792-801, 2006

Dusek RL, Chen F, Getsios S, Park JK, Amargo EV, Cryns VL, Green KJ. The Differentiation-dependent Desmosomal Cadherin Desmoglein 1 Is a Novel Caspase-3 Target That Regulates Apoptosis in Keratinocytes. J. Biol. Chem. 281: 3614-24, 2006.

Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 99:646-55, 2006.

Godsel LM, Hsieh SN, Amargo EV, Bass AE, Pascoe-McGillicuddy LT, Huen AC, Thorne ME, Gaudry CA, Park JK, Myung K, Goldman RC, Chew L, Green KJ. Desmoplakin assembly dynamics in 4D: multiple phases differentially regulated by intermediate filaments and actin. J. Cell Biol. 171: 1045-1060, 2005.