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Navin Viswakarma, PhD
Research Assistant Professor of Pathology
Ward 7-106
303 E. Chicago Avenue
Chicago, IL 60611
n-viswakarma@northwestern.edu
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Phone: (312) 503-1439
Fax: (312) 503-8240
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Medical School
National Research Center on Plant Biotechnology, India
Research Interests
The major focus of our laboratory is to elucidate the mechanism of signal transduction by which nuclear receptor and associated coactivators regulate gene expression in tissue/cell specific manner. To understand the biological role of nuclear receptors and coactivators, our lab is using genetically modified (transgenic and gene knock-out) mouse models of novel coactivators which are identified and characterized in our lab and study their biological significance in mammalian development and various diseases like obesity, diabetes and cancer.
Selected Publications
Yu S, Viswakarma N, Batra SK, Rao MS, Reddy J. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Biochimie, 86: 743-761, 2004.
Surapureddi S, Viswakarma N, Yu S, Guo D, Rao MS, Reddy JK. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex. Biochem Biophys Res Comm 343: 535-543, 2006
Guo D, Sarkar J, Ahmed M, Viswakarma N, Jia Y, Yu S, Rao MS, Reddy JK. Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Biochem Biophys Res Comm 347: 485-495, 2006
Matsumoto K, Yu S, Jia Y, Ahmed MR, Viswakarma N, Sarkar J, Kashireddy PV, Rao MS, Karpus W, Gonzalez FJ, Reddy JK. Critical role for transcription coactivator PBP/TRAP220 in liver regeneration, and PPARalpha ligand-induced tumor development. J Biol Chem 282:17053-17060, 2007
Sarkar J, Qi C, Guo D, Ahmed MR, Jia Y, Usuda N, Viswakarma N, Rao MS, Reddy JK, Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PPAR and CAR, the constitutive androstane receptor, in mouse liver. Gene Expression, 13: 255-269, 2007
Jia Y, Viswakarma N, Matsumoto K, Sarkar J, Fitchev PF, Pyper SR, Guo D, Walton ZR, Crawford SE, Karpus WL, Rao MS, Zhu YJ, Reddy JK) Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCoA6IP gene. Communicated in Molecular and Cellular Biology 2008.
Viswakarma N, Yu S, Naik S, Kashireddy P, Matsumoto K, Sarkar J, Surapureddi S, Jia Y, Rao MS, Reddy JK Transcriptional regulation of mitochondrial cell death-inducing DNA fragmentation factor alpha-like effector A (Cidea) in mouse liver by PPARa and PPAR?. J Biol Chem 282: 18613-18624, 2007.
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