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Jiansheng Huang, PhD
Research Assistant Professor of Pathology
Ward 7-106
303 E. Chicago Avenue
Chicago, IL 60611
jiansheng-huang@northwestern.edu
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Phone: (312) 503-1439
Fax: (312) 503-8240
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Medical School
First Military Medical University, China
/ Fudan University, China
Site of Fellowship
Baylor College of Medicine (Immunology)
/ University of Kansas Medical Center (Pharmacology)
University of Utah (Human Cancer)
Research Interests
I am mainly involved in uncovering the mechanisms of endoplasmic reticulum stress in regulation of
metabolic disorder and hepatocarcinogenesis based on the acyl-CoA oxidase 1 deficient (Acox1-/-),
leptin and Acox1 double deficient (ob-/-Acox1-/-), and Promethin deficient (Prom-/-) mice.
Selected Publications
Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, Osborne TF. Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase. J Lipid Res. 47:2754-61, 2006
Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 20:2671-81, 2006.
Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, Moore DD, Wang L. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology. 46:147-57, 2007
He N, Park K, Zhang Y, Huang J, Lu S, Wang L. Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. Gastroenterology, 2008;134(3):793-802
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