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Jian-Jun Wei, MD
Associate Professor of Pathology
Feinberg 7-334
251 E. Huron Street
Chicago, IL 60611
jianjun-wei@northwestern.edu
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Phone: (312) 926-1815
Fax: (312) 926-3127
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Anatomic Pathology Division
Surgical Pathology
Medical School
Huabei Medical College, China
Site of Residency
Indiana University (Medical Genetics)
/ New York University (Pathology)
Site of Fellowship
New York University (Gyne Pathology)
Research Interests
My major research interests are on identification of molecular biomarkers that are associated with tumor growth and progression in benign and malignant uterine smooth muscle tumors. In addition, I am interested in
characterization of the role of microRNAs in the pathogenesis of benign and malignant tumors in women's reproductive organs through regulation of the target gene expression.
Selected Publications
Wei JJ, Chiriboga L, Arslan AA, Melamed J, Yee H, Mittal K. Ethnic differences in expression of the dysregulated proteins in uterine leiomyomata. Hum Reprod. 21:57-67, 2006.
Wei JJ, Zhang XM, Chiriboga L, Yee H, Perle MA, Mittal K. Spatial differences in biologic activity of large uterine leiomyomata. Fertil Steril. 85:179-87, 2006
Peng Y, Chen F, Melamed J, Chiriboga L, Wei JJ, Kong X, McLeod M, Li Y, Li CX, Feng A, Garabedian MJ, Wang Z, Roeder RG, Lee P. Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci USA 105:5236-41, 2008
Cai C, P Yi, Wei JJ, T. Michael. F Chen, L W. Gerald, M R. Pincus, I Osman, P Lee. Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations. Oncogene 27:3201-10, 2008.
Zou Y, Liu Q, Chen B, Zhang X, Guo C, Wei JJ, Shao C, Gong Y. Mutation in CUL4B, a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet 80:561-566, 2007
Wang T, Zhang X, Obijuru L, Laser J, Aris V, Lee P, Mittal K, Soteropoulos P, Wei JJ. A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. Genes Chromosomes Cancer. 46:336-47, 2007.
Peng L, Wen Y, Han Y, Wei A, Shi G, Mizuguchi M, Lee P, Hernando E, Mittal K, Wei JJ. Expression of insulin-like growth factors (IGFs) and IGF signaling: Molecular complexity in uterine leiomyomas. Fertil & Steril (Apr 24 online), 2008.
Peng Y, Laser J, Mittal K, Shi G, Lee P, Wei JJ. Antiproliferative effects by let-7 repression of high-mobility group A2 in prostate cancer and uterine leiomyoma. Mol Cancer Res 6:663-73, 2008.
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