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Kathleen Green, PhD
Mayberry Professor of Pathology
Professor of Dermatology
Associate Chairman of Pathology
Tarry 7-729
303 E. Chicago Avenue
Chicago, IL 60611
kgreen@northwestern.edu
http://www.kgreen.northwestern.edu
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Phone: (312) 503-5300
Lab: (503) 503-5069
, Lab: (312) 503-2127
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Medical School
Washington University in St. Louis (PhD; Cell and Developmental Biology)
Site of Fellowship
Northwestern University Medical School
Research Interests
Our laboratory is interested in the function and regulation
of intercellular
junction molecules in desmosomes and adherens junctions that act to mediate
cell-cell adhesion and attachment of the cytoskeleton to the cell surface.
Defects in junctional components caused by mutation or post-translational
modification result in a variety of pathologies ranging from skin and
cardiac disease to cancer. In addition, junction-associated molecules
are involved in non-junctional functions such as signaling in development
and differentiation. The lab uses a multi-faceted approach to dissect
the function of cadherins, armadillo and plakin family junction components
including but not limited to collaborative atomic structure determinations,
molecular genetics, live cell imaging and trangenic mouse approaches.
Selected Publications
Getsios S, Huen AC, Green, KJ. Working out the strength and flexibility of desmosomes. Nature Reviews Cell Mol. Biol. 5: 271-281, 2004
Chen X, Kojima S, Borisy GG, Green KJ. P120 catenin associates with kinesin and facilitiates the transport of cadherin-catenin complexes to intercellular junctions. J. Cell Biol. 163: 547-557, 2003.
Yin T, Getsios S, Caldelari R, Kowalczyk AP, Muller EJ, Jones JC, Green KJ. Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanisms. Proc Natl Acad Sci U S A. 102):5420-5, 2005
Godsel LM, Hsieh SN, Amargo EV, Bass AE, Pascoe-McGillicuddy LT, Huen AC, Thorne ME, Gaudry CA, Park JK, Myung K, Goldman RC, Chew L, Green KJ. Desmoplakin assembly dynamics in 4D: multiple phases differentially regulated by intermediate filaments and actin. J. Cell Biol. 171: 1045-1060, 2005.
Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 99:646-55, 2006.
Dusek RL, Chen F, Getsios S, Park JK, Amargo EV, Cryns VL, Green KJ. The Differentiation-dependent Desmosomal Cadherin Desmoglein 1 Is a Novel Caspase-3 Target That Regulates Apoptosis in Keratinocytes. J. Biol. Chem. 281: 3614-24, 2006.
Dusek RL, Godsel LM, Chen F, Strohecker AM, Getsios S, Harmon R, Muller EJ, Caldelari R, Cryns VL, Green KJ. Plakoglobin Deficiency Protects Keratinocytes from Apoptosis. J Invest Dermatol. 127:792-801, 2006
Bass Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK, Denning M, Green KJ. Plakophilin 2: a critical scaffold for PKC-alpha that regulates intercellular junction assembly. J. Cell Biol. 181: 605-13, 2008
View more Publications by Kathleen Green, PhD
listed in the National Library of Medicine (PubMed)
Recommended Resources
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