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William Karpus, PhD
Fleming Professor of Pathology
Professor of Microbiology-Immunology
Ward 3-290
303 E. Chicago Avenue
Chicago, IL 60611
w-karpus@northwestern.edu
http://www.karpuslab.northwestern.edu
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Phone: (312) 503-1005
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Clinical Pathology
Flow Cytometry
Medical School
Wayne State University School of Medicine (PhD; Immunology-Microbiology)
Site of Fellowship
Northwestern University Medical School
Research Interests
In my laboratory we study the cellular and molecular
mechanisms of immunopathogenesis of T cell-mediated central nervous system (CNS) demyelinating diseases, the
chemokine regulation of cell migration and host responses to mucosal bacterial infection, and the role of chemokines in the migration of B cell lymphoma. The laboratory employs two mouse models of multiple sclerosis (MS): Theiler's virus-induced demyelinating disease (a virus-induced model of MS) and experimental autoimmune encephalomyelitis (EAE) (an autoimmune model of MS). In particular, the laboratory is examining the chemokine and chemokine receptor biology of T cell, monocyte, and dendritic cell recruitment during CNS demyelinating
disease. In addition, we are examining the balance between cellular and molecular mechanisms of oral tolerance induction and generation of mucosal
immunity/host defense to bacterial and viral pathogens. Finally, the laboratory uses a model of murine B cell lymphoma to study the mechanisms of tumor cell migration to lymphoid and extra-lymphoid tissues.
The approaches utilized in the laboratory are applicable to both the understanding of basic biologic mechanisms of
disease progression and treatment of autoimmune diseases, enhancement of immunity to pathogens, and treatment of cancer.
Selected Publications
Karpus W, Lukacs NW, McRae BL, Strieter RM, Kunkel SL, Miller SD. An important role for the chemokine MIP-1alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J. Immunol. 155: 5003-5010, 1995.
Fife BT, Huffnagle G, Kuziel W, Karpus WJ. CC chemokine receptor 2 is critical for the induction of experimental autoimmune
encephalomyelitis. J. Exp. Med. 192: 899-906, 2000.
Depaolo RW, Lathan R, Rollins BJ, Karpus WJ. CCL2 is required for control of murine gastric Salmonella infection. Infect Immun 73:6514-22, 2005.
Karpus WJ, Kennedy KJ, Fife BT, Bennett JL, Dal Canto MC, Kunkel SL, Lukacs NW. Anti-CCL2 treatment inhibits Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neurovirol. 12:251-61, 2006.
Bennet JL, Elhofy A, Charo I, Miller SD, Dal Canto MC, Karpus WJ. CCR2 regulates development of Theiler's murine encephalomyelitis virus-induced demyelinating disease. Viral Immunol. 20: 19-33, 2007.
Dogan RNE, Elhofy A, Karpus WJ. Production of CCL2 by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells. J. Immunol. 180: 7376-7384, 2008
Karpus WJ, Reynolds N, Behanna HA, Van Eldik LI, Watterson DM. Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight pro-inflammatory cytokine suppressing drug. J. Neuroimmunol. (in press), 2008.
Thompson WL, Karpus WJ, Van Eldik LI. MCP-1 deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory to peripheral endotoxin insult. J. Neuroinflam. (in press), 2008.
View more Publications by William Karpus, PhD
listed in the National Library of Medicine (PubMed)
Recommended Resources
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