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Eileen H. Bigio, MD
Steiner Professor of Pathology
Northwestern ADC Neuropathology Core Leader
Medical Director, Neuropathology
Olson 2-458
710 N. Fairbanks Court
Chicago, IL 60611
e-bigio@northwestern.edu
http://www.brain.northwestern.edu
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Phone: (312) 926-9543
Fax: (312) 926-9830
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Anatomic Pathology Division
Neuropathology
Medical School
University of Texas Medical Branch at Galveston
Site of Residency
University of Texas Southwestern Medical School in Galveston
Site of Fellowship
University of Texas Southwestern Medical Center
Research Interests
My research interests lie in the area of neurodegenerative disease, particularly Alzheimer's disease and related disorders such as the frontotemporal lobar degenerations and motor neuron disease. My focus is on the role of genetics and morphologic abnormalities such as parenchymal vacuolation and ubiquitin, TDP-43, and tau positive inclusions in frontotemporal lobar degenerations and related disorders such as primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease-associated dementia. In addition, I continue my role of Neuropathology Core leader in the NIH-supported Cognitive Neurology and Alzheimer Disease Center at Northwestern University Feinberg School of Medicine. Within the framework of the Core-related Laboratory for Cognitive and Molecular Morphometry, the Neuropathology Core is actively involved in assisting basic science researchers investigate the applicability of their findings to human tissue.
Selected Publications
Bigio EH: Making the diagnosis of frontotemporal lobar degeneration. [Invited Review] Arch Pathol Lab Med 137:314-325;2013 23451743
Bigio EH, Wu JY, Deng H-X, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M. Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS
Bigio EH. Motor neuron disease: The C9orf72 hexanucleotide repeat expansion in FTD and ALS. [Invited News and Views Commentary] Nature Reviews Neurology 8:249-250;2012
Bigio EH. . C9ORF72, the new gene on the block, causes C9FTD/ALS: new insights provided by neuropathology. [Invited Editorial] Acta Neuropathol DOI 10.1007/s00401-011-0919-7;2011
Halliday G, Bigio EH., Cairns NJ, Neumann M, Mackenzie IR, Mann DM, Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol 63:709-719;2008.
Bigio EH., Weintraub S, Rademakers R, Baker M, Ahmadian SS, Rademaker A, Weitner BB, Mao Q, Lee K-H, Mishra M, Ganti RA, Mesulam M-M. Frontotemporal lobar degeneration with TDP-43 proteinopathy and chromosome 9p repeat expansion in C9ORF72: clinicopathologic correlation. Neuropathology 2012 Jun 18. doi:10.1111/j.1440-1789.2012.01332.x
Montine TJ, Phelps CH, Beach TG, Bigio EH., Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT. TAR DNA-binding protein-43 in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer disease. Acta Neuropathol 116:135140;2008.
Guo W, Chen Y, Zhou X, Kar A, Ray P, Chen X, Rao EJ, Yang M, Ye H, Zhu L, Liu J, Zhang D, Buratti E, Baralle FE, Bigio EH,, Mesulam M, Xu Q, Shen Y, Fushimi K, Wu JY. . An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nature Struct Mol Biol 18:822-830;2011
View more Publications by Eileen H. Bigio, MD
listed in the National Library of Medicine (PubMed)
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