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Eileen H. Bigio, MD
Professor of Pathology
Director, Northwestern ADC Neuropathology Core
Olson 2-459
710 N. Fairbanks Court
Chicago, IL 60611
e-bigio@northwestern.edu
http://www.brain.northwestern.edu
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Phone: (312) 926-9543
Fax: (312) 926-9830
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Anatomic Pathology Division
Neuropathology
Medical School
University of Texas Medical Branch at Galveston
Site of Residency
University of Texas Southwestern Medical School in Galveston
Site of Fellowship
University of Texas Southwestern Medical Center
Research Interests
My research interests lie in the area of neurodegenerative disease, particularly Alzheimer's disease and related disorders such as the frontotemporal lobar degenerations and motor neuron disease. My focus is on the role of genetics and morphologic abnormalities such as parenchymal vacuolation and ubiquitin, TDP-43, and tau positive inclusions in frontotemporal lobar degenerations and related disorders such as primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, and motor neuron disease-associated dementia. In addition, I continue my role of Neuropathology Core leader in the NIH-supported Cognitive Neurology and Alzheimer Disease Center at Northwestern University Feinberg School of Medicine. Within the framework of the Core-related Laboratory for Cognitive and Molecular Morphometry, the Neuropathology Core is actively involved in assisting basic science researchers investigate the applicability of their findings to human tissue.
Selected Publications
Lipton AM, White III CL, Bigio EH: Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration. Acta Neuropathologica 2004;108:379-385.
Cairns NJ, Bigio EH, Mackenzie IRA, Neumann M, Lee VM-Y, Hatanpaa KJ, White III CL, Schneider JA, Tenenholz-Grinberg L, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, Munoz DG, Dickson DW, Ince PG, Trojanowski JQ, Mann DMA. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 114:5-22;2007.
Mishra M, Paunesku T, Woloshak GE, Siddique T, Zhu L, Lin S, Greco K, Bigio EH. Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions. Acta Neuropathol 114;81-94;2007.
Davion S, Johnson N, Weintraub S, Mesulam M-M, Engberg A Mishra M, Baker M, Adamson J, Hutton M, Rademakers R, Bigio EH. Clinicopathologic correlation in PGRN mutations. Neurology 69:1113-1121;2007.
Mesulam M, Wicklund A, Johnson N, Rogalski E, Leger G, Rademaker F, Weintraub S, Bigio EH. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol 63:709-719;2008.
Bigio EH. Update on Recent Molecular and Genetic Advances in Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol 67:635-648;2008.
Bigio EH. TAR DNA-binding protein-43 in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer disease. Acta Neuropathol 116:135140;2008.
Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, Akiyama H, Baborie A, Spina S, Dickson DW, Trojanowski JQ, Mann DM. Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol 117:1518;2009.
View more Publications by Eileen H. Bigio, MD
listed in the National Library of Medicine (PubMed)
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