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Paul Lindholm, MD
Associate Professor of Pathology
Director of the Hemostasis/Coagulation Laboratories
Feinberg 7-514C
251 E. Huron Street
Chicago, IL 60611
p-lindholm@northwestern.edu
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Phone: (312) 926-8483
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Clinical Pathology
Blood Bank
Hemostasis-Coagulation
Medical School
University of Minnesota
Site of Residency
University of Minnesota
Site of Fellowship
National Institute of Health
Research Interests
Our laboratory focuses on the mechanisms by which prostate cancer cells invade surrounding tissues and spread to distant sites in the body, leading to prostate cancer morbidity and death. We have characterized prostate cancer cell lines and found that the ras homolog RhoA and the nuclear transcription factor NF-kappaB are active and necessary for highly invasive prostate cancer cell behavior. Furthermore, RhoA activity is sufficient to increase prostate cancer cell invasion, motility and NF-kappaB activity. These studies suggest that up-regulation of a RhoA-NF-kappaB pathway may be a mechanism by which multiple types of aggressive tumor cells invade. These cellular signaling molecules likely effect the expression of growth factors and extracellular proteases which promote cancer cell invasion and metastasis. A major emphasis is being placed on determining how RhoA and NF-kappaB expression and activity is related to the grade and stage in clinical prostate cancer. Our present studies are further designed to discover the extracellular growth factors and proteases under the control of RhoA and NF-kappaB that participate in prostate cancer cell invasive and metastatic behavior. By identifying the mediators of prostate cancer cell invasion and metastasis, we hope to discover critical steps of cancer cell invasion and metastasis and find targeted strategies to block malignant prostate cancer progression.
Selected Publications
Hwang YS, Hodge JC, Sivapurapu N, Lindholm PF. Lysophosphatidic acid stimulates PC-3 prostate cancer cell matrigel invasion through activation of RhoA and NF-kappaB activity. Mol Carcinog 45:518-529 2006
Yemelyanov A, Gasparian A, Lindholm P, Dang L, Pierce JW, Kisseljov F, Karseladze A, Budunova I. Effects of IKK inhibitor PS1145 on NF-?B function, proliferation, apoptosis and invasion activity in prostate carcinoma cells. Oncogene 25:387-398, 2006
View more Publications by Paul Lindholm, MD
listed in the National Library of Medicine (PubMed)
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