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Dennis Solt, DMD, PhD
Associate Professor of Pathology
Associate Professor of Surgery
Director, Oral Pathology Laboratory
Ward 6-155
303 E. Chicago Avenue
Chicago, IL 60611
d-solt@northwestern.edu
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Phone: (312) 503-1314
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Anatomic Pathology Division
Oral Pathology
Medical School
University of Pittsburgh School of Dental Medicine
Site of Residency
Toronto General Hospital
/ Temple University (PhD; Experimental Pathology
Research Interests
Squamous cell carcinoma and precancerous lesions histologically
indistinguishable from those arising in tobacco-exposed oral mucosa can
be induced in the hamster buccal pouch by topical application of chemical
carcinogens. We are employing this model to clarify the cellular and molecular
mechanisms involved in chemical squamous mucosal carcinogenesis and for
the development of novel strategies for cancer chemoprevention and therapy.
Selected Publications
Solt DB, Medline A, Farber E. Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the
sequential analysis of liver carcinogenesis. Am. J. Pathol. 88:595-618, 1977.
Solt DB, Shklar G. Rapid induction of gamma-glutamyl transpeptidase-rich intraepithelial clones in 7,12-dimethylbenz(a)anthracene-treated hamster buccal pouch. Cancer Res. 42:285-291, 1982.
Chang K-W, Sarraj S, Lin S-C, Tsai P-I, Solt D. p53 and Ha-ras mutation and telomerase activation during nitrosamine-mediated hamster pouch carcinogenesis. Carcinogenesis. 21:1441-1451, 2000.
Shabany K, Chiu P, Ragian E, Chang K-W, Solt D. Rapid in vivo assay for topical oral cancer chemopreventive agents. Int. J. Oncol. 21:159-164, 2002.
Solt D, Chang K-W, Helenowski I, Rademaker A. Phenethyl isothiocyanate inhibits nitrosamine-mediated carcinogenesis in hamster buccal pouch epithelium. Cancer Lett. 202:147-152. 2003
Ariztia EV, Subbarao V, Solt DB, Rademaker AW, Iyer AP, Oltvai ZN. Osteopontin contributes to hepatocyte growth factor-induced tumor growth and metastasis formation. Exp Cell Res. 288:257-67, 2003
View more Publications by Dennis Solt, DMD, PhD
listed in the National Library of Medicine (PubMed)
Recommended Resources
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