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Anjen Chenn, MD, PhD
Associate Professor of Pathology
Director, Diagnostic Molecular Biology Laboratory
Ward 3-200
303 E. Chicago Avenue
Chicago, IL 60611
achenn@northwestern.edu
http://www.chennlab.northwestern.edu
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Phone: (312) 503-4468
Fax: (312) 503-8240
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Clinical Pathology
Molecular Diagnostics
Medical School
Stanford University Medical School
Site of Residency
Brigham and Women's Hospital
/ Stanford University Medical School (PhD; Neurosciences)
Site of Fellowship
Beth Israel Hospital
Research Interests
Our major research interest is understanding the factors that control cell proliferation and differentiation in the developing mammalian central nervous system. Although the mechanisms that regulate cell proliferation during neural development are poorly understood, studies in other tissues suggest that loss of normal cell polarity and tissue architecture play crucial regulatory roles in cell proliferation and cancer. Our most recent work suggests that beta catenin, an integral component of the adherens junction, can regulate cell cycle re-entry and differentiation in the developing mammalian brain. Transgenic mice expressing a truncated, stabilized form of beta catenin develop massively enlarged brains with increased cerebral cortical surface area and folds resembling sulci and gyri of higher mammals. Understanding the biology of epithelial organization can lend insight onto the regulation of proliferation during neural development and ultimately reveal mechanisms underlying developmental brain disorders and tumors in the central nervous system.
Selected Publications
Chenn A, McConnell SK. Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. Cell 82, 631-641. [cover illustration], 1995.
Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297, 365-369. [cover illustration], 2002.
Chenn A. Eppendorf & Science Prize. Essays on science and society. Making a bigger brain by regulating cell cycle exit. Science 298, 766-767, 2002.
Chenn A. The simple life (of cortical progenitors). Neuron. 45:817-819, 2005
Windler-Hart SL, Chen KY, Chenn A. A cell behavior screen: identification, sorting, and enrichment of cells based on motility. BMC Cell Biol. 6:14, 2005
Stocker AM, Chenn A. Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex. Brain Res 1073-1074:151-158, 2006
Sheen VL, Ferland RJ, Neal J, Harney M, Hill RS, Banham A, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA. Neocortical neuronal arrangement in Miller Dieker syndrome. Acta Neuropathol (Berl) 111:489-96., 2006
Sheen VL, Ferland RJ, Harney M, Hill RS, Neal J, Banham AH, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA. Impaired proliferation and migration in human Miller-Dieker neural precursors. Ann Neurol. 60:137-144 2006
View more Publications by Anjen Chenn, MD, PhD
listed in the National Library of Medicine (PubMed)
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