Anatomic Pathology Division
Autopsy
Pediatric Pathology
Clinical Pathology
Medical School
University of Guadalajara, 1986
Site of Residency
University of Cincinnati Hospital, 1996
Site of Fellowship
Cincinnati Children's Hospital, 1998
Research Interests
Pediatric liver diseases
Selected Publications
 Whitington PF, Malladi P, Melín-Aldana H, Azzam R, Mack CL, Sahai A. Hepatic expression of osteopontin correlates with bile duct proliferation and fibrosis in biliary atresia. Submitted for publication.
Sahai A, Malladi P, Melín-Aldana H, Green RM, Whitington PF. Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a murine model. Am J Physiol Gastrointest Liver Physiol 2004.
Jacobsohn DA, Emerick KM, Scholl P, Melín-Aldana H, O'Gorman M, Duerst R, Kletzel M. Nonmyeloablative hematopoietic stem cell transplant for X-linked hyper-immunoglobulin M syndrome with cholangiopathy. Pediatrics 2004;113:e122-e127.
Sundaram S, Sunku B, Nelson SP, Sentongo T, Melín-Aldana H, Kumar R, Li BUK. Adherent white plaques: an endoscopic finding in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2004;38:208-12.
Kumar R, Sentongo T, Nelson SP, Melín-Aldana H, Li BUK. Eosinophilic esophagitis in children. Clin Appl Immunol Rev. 2003;4:173-88.
Melín-Aldana H, Sciortino D. Virtual reality demonstration of surgical specimens, including links to histologic features. Mod Pathol 2003;16:958-61.
Currier AR, Sabla G, Locaputo S, Melín-Aldana H, Degen JL, Bezerra JA. Plasminogen directs the pleiotrophic effects of uPA in liver injury and repair. Am J Physiol Gastrointest Liver Physiol 2003;284:G508-15.
Ng VL, Sabla GE, Melín-Aldana H, Kelley-Loughnane N, Degen JL, Bezerra JA. Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury. J Hepatol 2001;35:781-9 .
Pohl JF, Melín-Aldana H, Sabla G, Degen JL, Bezerra JA. Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury. Am J Pathol 2001;159:2179-86.
Bezerra JAB, Currier AG, Melín-Aldana H, Sabla G, Bugge TH, Kombrick KW, Degen JL. Plasminogen activators direct reorganization of the liver lobule after acute injury. Am J Pathol 2001;3:921-929 .
Pohl J, Melín-Aldana H, Rudolph C. Prolapse gastropathy in the pediatric patient. J Pediat Gastroenterol Nutrition 2000;30:458-60.
Bezerra JA, Bugge TH, Melín-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL. Plasminogen deficiency leads to impaired remodeling following a toxic injury to the liver. Proc Natl Acad Sci USA 1999; 96: 15143-8 .
Abstracts:
Whitington PF, Malladi P, Melín-Aldana H, Mack CM, Sahai A. Upregulation of a TH1 cytokine osteopontin in patients with biliary atresia: Differential localization at diagnosis and at transplant. Hepatology 2003;38:525A
Melín-Aldana H, Goethals D, Chou PM. Computer-based demonstration of surgical specimens, with rotation in a full 360 degree plane and active links to microscopic features. Mod Pathol 2002;15:342A
Ng VL, Sabla GE, Melín-Aldana H, Bezerra JA. Plasminogen deficiency perpetuates the activated phenotype of hepatic stellate cells after an injury. J Pediat Gastroenterol Nutrition 2000;31:S185
B Pohl JF, Melín-Aldana H, Sabla GE, Degen JL, Bezerra JA. Plasminogen deficiency accelerates the development of hepatic fibrosis. J Pediat Gastroenterol Nutrition 2000;31:S266
Ng VL, Sabla GE, Melín-Aldana H, Bezerra JA. Plasminogen deficiency perpetuates the activated phenotype of hepatic stellate cells after an injury. Gastroenterology 2000;118:A988
Pohl JF, Melín-Aldana H, Sabla GE, Degen JL, Bezerra JA. Plasminogen deficiency accelerates the development of hepatic fibrosis. Gastroenterology 2000;118:A989
Bezerra JA, Bugge TH, Melín-Aldana H, Sabla G, Kombrick K, Witte DP, Degen JL. Plasminogen activators direct matrix remodeling following an acute liver injury. Hepatology 1999;30:490A
Bezerra JA, Bugge TH, Melín-Aldana H, Witte DP, Degen J. Impaired liver remodeling in plasminogen-deficient mice. Presented at the 1999 annual meeting of the American Gastroenterological Association. Orlando, Florida May 16-19
Melín-Aldana H, Bezerra JA. Impaired regeneration in the developing liver of interleukin-6-deficient mice. Presented at the 1999 annual meeting of the American Gastroenterological Association. Orlando, Florida May 16-19
Recommended Resources
Society for Pediatric Pathology, United States and Canadian Academy of Pathology and the Hans Popper Hepatopathology Society.
|
