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Lisa Godsel, PhD
Research Assistant Professor of Pathology
Tarry 7-729
303 E. Chicago Avenue
Chicago, IL 60611
l-godsel@northwestern.edu
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Phone: (312) 503-5069
Fax: (312) 503-8240
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Medical School
Northwestern University
Site of Fellowship
Post Doctoral Fellowship, Northwestern University
Research Interests
I am interested in the regulation of the intercellular adhesive junction, the desmosome, during processes such as wound healing and morphogenesis. Currently my studies are focused on the plakin protein, desmoplakin, an obligate member of the desmosomal plaque, which mediates the interaction between the plaque and the intermediate filament network. This interaction with the intermediate filament network is required for maintaining tissue integrity, particularly those tissues undergoing large amounts of stress, such as the heart and skin. The importance of desmoplakin in maintaining adhesive strength is highlighted by cardiomyopathies and skin diseases, which result from desmoplakin mutations. Utilizing biochemistry and fixed and live cell imaging techniques we are analyzing the dynamics of desmoplakin during desmosome formation and the roles the intermediate filament and microfilament networks play in that process.
Selected Publications
Yin T, Getsios S, Caldelari R, Godsel LM, Kowalczyk AP, Muller EJ, Green KJ. Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor. J Biol Chem 280:40355-63, 2005.
Godsel LM, Hsieh SN, Amargo EV, Bass AE, Pascoe-McGillicuddy LT, Huen AC, Thorne ME, Gaudry CA, Park JK, Myung K, Goldman RD, Chew TL, Green KJ. Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J Cell Biol. 171:1045-59, 2005.
Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA.Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 99:646-55, 2006.
Dusek RL, Godsel LM, Chen F, Strohecker AM, Getsios S, Harmon R, Muller EJ, Caldelari R, Cryns VL, Green KJ. Plakoglobin Deficiency Protects Keratinocytes from Apoptosis. J Invest Dermatol. 2006 (epub ahead of print).
View more Publications by Lisa Godsel, PhD
listed in the National Library of Medicine (PubMed)
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