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Guang-Yu Yang, MD, PhD
Calandra Professor of Pathology
Director, Surgical Pathology
Ward 6-116
303 E. Chicago Avenue
Chicago, IL 60611
g-yang@northwestern.edu
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Phone: (312) 503-0645
Fax: (312) 503-0647
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Surgical Pathology
Medical School
China Medical University
Site of Residency
New York University Medical Center
Site of Fellowship
Johns Hopkins Hospital
Research Interests
The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are 1) to develop a molecular mimicking model of ulcerative colitis-associated carcinogenesis in rodents, and further to elucidate the role of inflammation-caused and dietary iron-enhanced nitro-oxidative stress and inflammatory mediators in DNA damage, cell proliferation and inflammation-driven carcinogenesis; 2) to study the pathogenesis and molecular biomarkers of pancreatic carcinoma in genetically engineered mouse model and in human; and 3) to develop an efficient strategy on the prevention of chronic inflammation-driven carcinogenesis, particularly interested in dietary nutrients, antioxidants, green tea and inositol compounds and specifically targeted on colorectal, pancreatic, and liver carcinogenesis.
Selected Publications
Seril DN, Liao J, Yang CS, Yang G-Y. Systemic iron supplementation replenishes Iron stores without enhancing colon carcinogenesis in murine models of ulcerative colitis: Comparison with iron-enriched diet .J Neurosci. 2013 Mar 6;33(10):4570-83.
Seril DN, Liao J, West AB, Yang GY. High-iron diet: foe or feat in ulcerative colitis and ulcerative colitis-associated carcinogenesis. J Clin Gastroenterol. 40:391-7, 2006
Liao J, Seril DN, Yang AL, Lu GG, Yang GY. Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds.
Carcinogenesis. 28:446-54, 2007.
View more Publications by Guang-Yu Yang, MD, PhD
listed in the National Library of Medicine (PubMed)
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