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Yuzhi Jia, PhD
Research Assistant Professor of Pathology
Ward 7-030
303 E. Chicago Avenue
Chicago, IL 60611
y-jia@northwestern.edu
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Phone: (312) 503-1439
Fax: (312) 503-8240
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Medical School
Harbin Medical University, PR China
/ Nippon Medical School, Japan (PhD)
Site of Residency
The Second Hospital of Harbin Medical University, PR China
Site of Fellowship
Nippon Medical School, Japan
/ Northwestern University Feinberg School of Medicine
Research Interests
My research work is focused on studying the mechanisms that regulate the transcriptional activities of nuclear receptors. Nuclear receptors constitute a large superfamily of transcription factors that regulate a diverse array of biological processes, including development and neoplasia, as well as energy and xenobiotic metabolism. In order to initiate transcription, some more factors are required to interact with nuclear receptors and to regulate their activities. These factors are collectively called "nuclear receptor co-factors". Several co-factors have been identified by our studies. Generating mouse models using gene targeting technology to investigate the functions of these genes is in process.
Selected Publications
Viswakarma N, Yu S, Naik S, Kashireddy P, Matsumoto K, Sarkar J, Surapureddi S, Jia Y, Rao MS, Reddy JK. Transcriptional regulation of Cidea, mitochondrial cell death-inducing DNA fragmentation factor alpha-like effector A, in mouse liver by peroxisome proliferator-activated receptor alpha and gamma.
J Biol Chem. 282:18613-24, 2007.
Sarkar J, Qi C, Guo D, Ahmed MR, Jia Y, Usuda N, Viswakarma N, Rao MS, Reddy JK. Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PPARalpha and CAR, the constitutive androstane receptor, in mouse liver. Gene Expr. 13:255-69, 2007.
Guo D, Sarkar J, Suino-Powell K, Xu Y, Matsumoto K, Jia Y, Yu S, Khare S, Haldar K, Rao MS, Foreman JE, Monga SP, Peters JM, Xu HE, Reddy JK. Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. J Biol Chem. 282:36766-76, 2007
View more Publications by Yuzhi Jia, PhD
listed in the National Library of Medicine (PubMed)
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