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Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Message from the Vice Chair

"We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research 

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Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs via the descriptions below.

Affilated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Recent Publications

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.

Keener R, Chhetri SB, Connelly CJ, Taub MA, Conomos MP, Weinstock J, Ni B, Strober B, Aslibekyan S, Auer PL, Barwick L, Becker LC, Blangero J, Bleecker ER, Brody JA, Cade BE, Celedon JC, Chang YC, Cupples LA, Custer B, Freedman BI, Gladwin MT, Heckbert SR, Hou L, Irvin MR, Isasi CR, Johnsen JM, Kenny EE, Kooperberg C, Minster RL, Naseri T, Viali S, Nekhai S, Pankratz N, Peyser PA, Taylor KD, Telen MJ, Wu B, Yanek LR, Yang IV, Albert C, Arnett DK, Ashley-Koch AE, Barnes KC, Bis JC, Blackwell TW, Boerwinkle E, Burchard EG, Carson AP, Chen Z, Chen YI, Darbar D, de Andrade M, Ellinor PT, Fornage M, Gelb BD, Gilliland FD, He J, Islam T, Kaab S, Kardia SLR, Kelly S, Konkle BA, Kumar R, Loos RJF, Martinez FD, McGarvey ST, Meyers DA, Mitchell BD, Montgomery CG, North KE, Palmer ND, Peralta JM, Raby BA, Redline S, Rich SS, Roden D, Rotter JI, Ruczinski I, Schwartz D, Sciurba F, Shoemaker MB, Silverman EK, Sinner MF, Smith NL, Smith AV, Tiwari HK, Vasan RS, Weiss ST, Williams LK, Zhang Y, Ziv E, Raffield LM, Reiner AP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology and Hemostasis Working Group; TOPMed Structural Variation Working Group; Arvanitis M, Greider … See abstract for full author list ➔

Nat Commun. 2024 May 24;15(1):4417. doi: 10.1038/s41467-024-48394-y.

Scattered crypt intestinal epithelial cell apoptosis induces necrotizing enterocolitis via intricate mechanisms.

Subramanian S, Bu HF, Chou PM, Wang X, Geng H, Akhtar S, Du C, Tan SC, Ideozu JE, Tulluri A, Sun Y, Ding WX, De Plaen IG, Tan XD.

Cell Mol Gastroenterol Hepatol. 2024 May 22:S2352-345X(24)00118-8. doi: 10.1016/j.jcmgh.2024.05.012. Online ahead of print.

Glioblastoma Phagocytic Cell Death: Balancing the Opportunities for Therapeutic Manipulation.

Du R, Tripathi S, Najem H, Brat DJ, Lukas RV, Zhang P, Heimberger AB.

Cells. 2024 May 11;13(10):823. doi: 10.3390/cells13100823.

1,25-Dihydroxyvitamin D3 Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.

Johnson JR, Martini RN, Yuan YC, Woods-Burnham L, Walker M, Ortiz-Hernandez GL, Kobeissy F, Galloway D, Gaddy A, Oguejiofor C, Allen B, Lewis D, Davis MB, Kimbro KS, Yates CC, Murphy AB, Kittles RA.

Biology (Basel). 2024 May 15;13(5):346. doi: 10.3390/biology13050346.

Development and implementation of a nationwide multidrug-resistant organism tracking and alert system for Veterans Affairs medical centers.

Pfeiffer CD, Jones MM, Klutts JS, Francis QA, Flegal HM, Murray AO, Willson TM, Hicks NR, Evans CT, Evans ME.

Infect Control Hosp Epidemiol. 2024 May 24:1-6. doi: 10.1017/ice.2024.79. Online ahead of print.

Quantitative radiomics and qualitative LI-RADS imaging descriptors for non-invasive assessment of β-catenin mutation status in hepatocellular carcinoma.

Arefan D, D'Ardenne NM, Iranpour N, Catania R, Yousef J, Chupetlovska K, Moghe A, Sholosh B, Thangasamy S, Borhani AA, Singhi AD, Monga SP, Furlan A, Wu S.

Abdom Radiol (NY). 2024 May 23. doi: 10.1007/s00261-024-04344-2. Online ahead of print.

Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study.

Traore B, Kassogue Y, Diakite B, Diarra F, Cisse K, Kassogue O, Diarra M, Coulibaly A, Coulibaly B, Diallo H, Diarra Z, Ly M, Maiga A, Sissoko SB, Sissoko AS, Traore CB, Kamate B, Teguete I, Bah S, Dolo G, Gursel DB, Holl J, Hou L, Maiga M.

BMC Infect Dis. 2024 May 22;24(1):513. doi: 10.1186/s12879-024-09412-y.

Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases 2023.

Hynds RE, Magin CM, Ikonomou L, Aschner Y, Beers MF, Burgess JK, Heise RL, Hume PS, Krasnodembskaya AD, Mei SHJ, Misharin AV, Park JA, Reynolds SD, Tschumperlin DJ, Tanneberger AE, Vaidyanathan S, Waters CM, Zettler PJ, Weiss DJ, Ryan AL.

Am J Physiol Lung Cell Mol Physiol. 2024 May 21. doi: 10.1152/ajplung.00052.2024. Online ahead of print.

Non-epithelial Gene Expression Correlates with Symptom Severity in Adults with Eosinophilic Esophagitis.

Kim S, Morgenstern NB, Osonoi K, Aceves SS, Arva NC, Chehade M, Collins MH, Dellon ES, Falk GW, Furuta GT, Gonsalves NP, Gupta SK, Hirano I, Hiremath G, Katzka DA, Khoury P, Leung J, Pesek R, Peterson KA, Pletneva M, Spergel JM, Wechsler JB, Yang GY, Rothenberg ME, Shoda T.

J Allergy Clin Immunol Pract. 2024 May 18:S2213-2198(24)00529-4. doi: 10.1016/j.jaip.2024.05.015. Online ahead of print.

Susceptibility to innate immune activation in genetically-mediated myocarditis.

Selgrade DF, Fullenkamp DE, Chychula IA, Li B, Dellefave-Castillo L, Dubash AD, Ohiri J, Monroe TO, Blancard M, Tomar G, Holgren C, Burridge PW, George AL Jr, Demonbreun AR, Puckelwartz M, George SA, Efimov IR, Green KJ, McNally EM.

J Clin Invest. 2024 May 16:e180254. doi: 10.1172/JCI180254. Online ahead of print.

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