Research: Department of Pathology: Feinberg School of Medicine: Northwestern University

Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs via the descriptions below.

Carcinogensis/Neoplasia

Cell and Developmental Pathology

Inflammation/Immnology

Neuropathology

Areas of Research

Affilated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Recent Publications

Comparison of myeloid neoplasms with non-classic 3q26.2/MECOM vs classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles and molecular mechanisms of MECOM activation.

Gao J, Gurbuxani S, Zak T, Kocherginsky M, Ji P, Wehbe F, Chen Q, Chen YH, Lu X, Jennings L, Frankfurt O, Altman J, Sukhanova M.

Genes Chromosomes Cancer. 2021 Oct 20. doi: 10.1002/gcc.23004. Online ahead of print.

Therapeutic Emergency Use Authorizations (EUAs) During Pandemics: Double-Edged Swords.

Bhimraj A, Morgan RL, Shumaker AH, Lavergne V, Baden L, Cheng VC, Edwards KM, Gandhi RT, Gallagher JC, Muller WJ, O'Horo JC, Shoham S, Wollins DS, Falck-Ytter Y.

Clin Infect Dis. 2021 Oct 20:ciab880. doi: 10.1093/cid/ciab880. Online ahead of print.

Orthogonal ubiquitin transfer reveals human papillomavirus E6 downregulates nuclear transport to disarm interferon-γ dependent apoptosis of cervical cancer cells.

Wang Y, Liu R, Liao J, Jiang L, Jeong GH, Zhou L, Polite M, Duong D, Seyfried NT, Wang H, Kiyokawa H, Yin J.

FASEB J. 2021 Nov;35(11):e21986. doi: 10.1096/fj.202101232RR.

POST-ENDOSCOPY ESOPHAGEAL NEOPLASIA IN BARRETT'S ESOPHAGUS: CONSENSUS STATEMENTS FROM AN INTERNATIONAL EXPERT PANEL.

Wani S, Yadlapati R, Singh S, Sawas T, Katzka DA; Post-Endoscopy Esophageal Neoplasia Expert Consensus Panel.

Gastroenterology. 2021 Oct 13:S0016-5085(21)03620-9. doi: 10.1053/j.gastro.2021.09.067. Online ahead of print.

Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation.

Merlin J, Ivanov S, Dumont A, Sergushichev A, Gall J, Stunault M, Ayrault M, Vaillant N, Castiglione A, Swain A, Orange F, Gallerand A, Berton T, Martin JC, Carobbio S, Masson J, Gaisler-Salomon I, Maechler P, Rayport S, Sluimer JC, Biessen EAL, Guinamard RR, Gautier EL, Thorp EB, Artyomov MN, Yvan-Charvet L.

Nat Metab. 2021 Oct 14. doi: 10.1038/s42255-021-00471-y. Online ahead of print.

Blind color deconvolution, normalization, and classification of histological images using general super Gaussian priors and Bayesian inference.

Pérez-Bueno F, Vega M, Sales MA, Aneiros-Fernández J, Naranjo V, Molina R, Katsaggelos AK.

Comput Methods Programs Biomed. 2021 Oct 5;211:106453. doi: 10.1016/j.cmpb.2021.106453. Online ahead of print.

Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group.

Van Bockstal MR, Cooks M, Nederlof I, Brinkhuis M, Dutman A, Koopmans M, Kooreman L, van der Vegt B, Verhoog L, Vreuls C, Westenend P, Kok M, van Diest PJ, Nauwelaers I, Laudus N, Denkert C, Rimm D, Siziopikou KP, Ely S, Zardavas D, Roberts M, Floris G, Hartman J, Acs B, Peeters D, Bartlett JMS, Dequeker E, Salgado R, Giudici F, Michiels S, Horlings H, van Deurzen CHM.

Cancers (Basel). 2021 Sep 29;13(19):4910. doi: 10.3390/cancers13194910.

Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas.

Chen L, Niu Y, Wan X, Yu L, Zhang X, Strickland AL, Dong L, Zhou F, Lu W.

BMC Cancer. 2021 Oct 11;21(1):1095. doi: 10.1186/s12885-021-08792-7.

Probable drug-induced lupus erythematosus by zonisamide.

Safadi MG, Smith K, Hassan S, Patel V, Viglione M, Zahner SL.

JAAD Case Rep. 2021 Sep 14;17:4-6. doi: 10.1016/j.jdcr.2021.09.001. eCollection 2021 Nov.

FOREWORD: JASC special issue on education in cytopathology.

Nayar R, Monaco SE.

J Am Soc Cytopathol. 2021 Sep-Oct;10(5):445-446. doi: 10.1016/j.jasc.2021.07.004.

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