Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Message from the Vice Chair

"We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research 

Read Full Message

Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs via the descriptions below.

Affilated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Recent Publications

High Baseline High-Sensitivity Cardiac Troponin T Concentrations and Risk of Index Acute Myocardial Infarction.

Knott JD, Ola O, De Michieli L, Akula A, Yang EH, Gharacholou SM, Slusser J, Lewis B, Mehta RA, Gulati R, Sandoval Y, Jaffe AS.

Mayo Clin Proc. 2024 Mar 15:S0025-6196(24)00026-0. doi: 10.1016/j.mayocp.2023.12.019. Online ahead of print.

scENCORE: leveraging single-cell epigenetic data to predict chromatin conformation using graph embedding.

Duan Z, Xu S, Sai Srinivasan S, Hwang A, Lee CY, Yue F, Gerstein M, Luan Y, Girgenti M, Zhang J.

Brief Bioinform. 2024 Jan 22;25(2):bbae096. doi: 10.1093/bib/bbae096.

AASLD Practice Guideline on non-invasive liver disease assessments of portal hypertension.

Sterling RK, Asrani SK, Levine D, Duarte-Rojo A, Patel K, Fiel MI, Leung DH, Taouli B, Alsawas M, Murad MH, Dranoff J, Taddei TH, Rockey DC.

Hepatology. 2024 Mar 15. doi: 10.1097/HEP.0000000000000844. Online ahead of print.

AASLD Practice Guideline on imaging-based non-invasive liver disease assessments of hepatic fibrosis and steatosis.

Sterling RK, Duarte-Rojo A, Patel K, Asrani SK, Alsawas M, Dranoff J, Fiel MI, Murad MH, Leung DH, Levine D, Taddei TH, Taouli B, Rockey DC.

Hepatology. 2024 Mar 15. doi: 10.1097/HEP.0000000000000843. Online ahead of print.

Non-invasive liver disease assessment to identify portal hypertension: A systematic review supporting the AASLD Practice Guideline.

Rockey DC, Alsawas M, Rojo-Duarte A, Patel K, Levine D, Asrani SK, Hasan B, Nayfeh T, Alsawaf Y, Saadi S, Malandris K, Murad MH, Sterling RK.

Hepatology. 2024 Mar 15. doi: 10.1097/HEP.0000000000000841. Online ahead of print.

B cells mediate lung ischemia/reperfusion injury by recruiting classical monocytes via synergistic B cell receptor/TLR4 signaling.

Farahnak K, Bai YZ, Yokoyama Y, Morkan DB, Liu Z, Amrute JM, De Filippis Falcon A, Terada Y, Liao F, Li W, Shepherd HM, Hachem RR, Puri V, Lavine KJ, Gelman AE, Bharat A, Kreisel D, Nava RG.

J Clin Invest. 2024 Jan 23;134(6):e170118. doi: 10.1172/JCI170118.

Validation of a multiomic model of plasma extracellular vesicle PD-L1 and radiomics for prediction of response to immunotherapy in NSCLC.

de Miguel-Perez D, Ak M, Mamindla P, Russo A, Zenkin S, Ak N, Peddagangireddy V, Lara-Mejia L, Gunasekaran M, Cardona AF, Naing A, Hirsch FR, Arrieta O, Colen RR, Rolfo C.

J Exp Clin Cancer Res. 2024 Mar 15;43(1):81. doi: 10.1186/s13046-024-02997-x.

Informing immunotherapy with multi-omics driven machine learning.

Li Y, Wu X, Fang D, Luo Y.

NPJ Digit Med. 2024 Mar 14;7(1):67. doi: 10.1038/s41746-024-01043-6.

Associations of Kidney Tubular Biomarkers With Incident Macroalbuminuria and Sustained Low eGFR in DCCT/EDIC.

Limonte CP, Gao X, Bebu I, Seegmiller JC, Karger AB, Lorenzi GM, Molitch M, Karanchi H, Perkins BA, de Boer IH; DCCT/EDIC Research Group.

Diabetes Care. 2024 Mar 14:dc232196. doi: 10.2337/dc23-2196. Online ahead of print.

Corrigendum to "Expert management of congenital portosystemic shunts and their complications" [JHEP Reports 6 (2024)].

McLin VA, Franchi-Abella S, Brütsch T, Bahadori A, Casotti V, de Ville de Goyet J, Dumery G, Gonzales E, Guérin F, Hascoet S, Heaton N, Kuhlmann B, Lador F, Lambert V, Marra P, Plessier DA, Quaglia A, Rougemont AL, Savale L, Sarma MS, Sitbon O, Superina RA, Uchida H, van Albada M, Johannes van der Doef HP, Vilgrain V, Wacker J, Zwaveling-Soonawala N, Debray D, Wildhaber BE.

JHEP Rep. 2024 Jan 30;6(3):101024. doi: 10.1016/j.jhepr.2024.101024. eCollection 2024 Mar.

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