Skip to main content

Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Message from the Vice Chair

"We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research 

Read Full Message

Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs.

Research Areas

Affiliated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Research Resources

Recent Publications

PRRX1 -rearranged Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 18 Cases Including a Novel PRRX1::EP300 Fusion.

Dehner CA, Torres-Mora J, Thangaiah JJ, Oliveira A, Michal M, Malik F, Din NU, Hassan U, Maqbool H, Obeidin F, Caragea M, Lee CH, Schubart C, Agaimy A, Grundtmann B, Melchior L, Talman ML, Gross J, Cheah AL, Thway K, Fisher C, Antonescu CR, Linos K.

Am J Surg Pathol. 2026 Jan 1;50(1):31-40. doi: 10.1097/PAS.0000000000002472. Epub 2025 Oct 2.

Dendritic location of dystrophic neurites in FTLD-TDP type C with annexinopathy.

Kawles A, Zouridakis A, Nelson C, Keszycki R, Minogue G, Macomber A, Jamshidi P, Castellani RJ, Geula C, Gefen T, Mesulam MM.

Brain Pathol. 2026 Jan;36(1):e70032. doi: 10.1111/bpa.70032. Epub 2025 Jul 23.

Acute Placental Inflammation Is Associated with Reduced Progesterone Receptor Density in the Basal Decidua in Spontaneous Preterm Birth.

Suresh S, Freedman A, Hirsch E, Ernst LM.

Am J Perinatol. 2026 Jan;43(1):128-130. doi: 10.1055/a-2524-4053. Epub 2025 Feb 24.

NOX2-Dependent Phagocyte Signaling Mediates Silica-Induced Murine Lung Injury via Macrophage-Neutrophil Interactions.

Kusaka M, Sakamoto K, Ikeyama Y, Kondo Y, Hayashi T, Ando A, Mori Y, Sato T, Matsushima M, Suzuki A, Fujita S, Shiraki Y, Kawabe T, Enomoto A, Ishii KJ, Hashimoto N, Ishii M.

Inflammation. 2025 Dec 17;49(1):3. doi: 10.1007/s10753-025-02389-z.

c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT.

Bakırdöğen D, Görgülü K, Xin J, Richter L, Alcalá S, Ruiz-Cañas L, Dai C, Frank KJ, Wu N, Diakopoulos KN, Ozturk H, Demircioğlu D, Peschke K, Ranjan R, Fusco F, Martinez-Useros J, Fernandez-Aceñero MJ, Chhabra NF, López-Gil JC, Ai J, Ruess DA, Kaya-Aksoy E, Schmidt F, Kohlmann L, Berninger A, Yangin H, Schicktanz F, Steiger K, Demir IE, Schmid RM, Reichert M, Adli M, Lesina M, Sainz B Jr, Algül H.

Mol Cancer. 2025 Dec 15. doi: 10.1186/s12943-025-02486-5. Online ahead of print.

TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS.

Alessandrini F, Wright M, Kurosaki T, Perloff OS, Ngo M, Kofler JK, Donnelly CJ, Maquat LE, Kiskinis E.

Neuron. 2025 Dec 12:S0896-6273(25)00848-7. doi: 10.1016/j.neuron.2025.11.001. Online ahead of print.

Prevalence of depression in post-stroke aphasia: systematic review and meta-analysis.

Vogel-Eyny A, Jung YJ, Hyun J, Siegle E, Haroun A, Nahar S, Sarkas S, Shankman SA, Slattery S, Ashaie S.

BMC Neurol. 2025 Dec 12. doi: 10.1186/s12883-025-04570-1. Online ahead of print.

Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.

Ulugut H, Younes K, Montembeault M, Bertoux M, Irish M, Kumfor F, Fumagalli GG, Samanci B, Illán-Gala I, Thompson JC, Santillo AF, Englund E, Landqvist Waldö M, Riedl L, Van den Stock J, Vandenbulcke M, Vandenberghe R, Laforce R Jr, Ducharme S, Pressman PS, Caramelli P, Cruz de Souza L, Takada LT, Gurvit H, Diehl-Schmid J, Galimberti D, Pasquier F, Weintraub S, Miller BL, Sturm VE, Whitwell JL, Boeve B, Rohrer JD, Piguet O, Gorno-Tempini ML, Josephs KA, Snowden J, Rowe JB, Warren JD, Rankin KP, Pijnenburg YAL; International rtvFTD working group.

Commun Med (Lond). 2025 Dec 12;5(1):523. doi: 10.1038/s43856-025-01252-4.

Molecular effects of indoor tanning.

Gerami P, Tandukar B, Deivendran D, Olivares S, Chen L, Tang J, Tan T, Sharma H, Bandari AK, Cruz-Pacheco N, Chang D, Marty AL, Olshen A, Murad NF, Song J, Lee J, Yeh I, Shain AH.

Sci Adv. 2025 Dec 12;11(50):eady4878. doi: 10.1126/sciadv.ady4878. Epub 2025 Dec 12.

Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial.

Frank SJ, Busse PM, Lee JJ, Rosenthal DI, Hernandez M, Swanson DM, Garden AS, Gunn GB, Patel SH, Snider JW, Ma DJ, Molitoris JK, Lee NY, Parvathaneni U, McDonald MW, Kalman NS, Lin A, Mohammed N, Henson C, Hyde C, Bajaj GK, Katz SR, Dagan R, Morrison WH, Reddy JP, Fuller CD, Shah SJ, Phan J, Chronowski GM, Mayo L, Sturgis EM, Ferrarotto R, Zhu XR, Zhang X, Wang L, Hutcheson KA, El-Naggar AK, Moreno AC, Lee A, Spiotto MT, Gross ND, Lai SY, Liao JJ, Paly J, Liao Z, Foote RL; University of Texas MD Anderson Cancer Center Clinical Trial Consortium.

Lancet. 2025 Dec 11:S0140-6736(25)01962-2. doi: 10.1016/S0140-6736(25)01962-2. Online ahead of print.

Be a part of our future discoveries.Giving

Follow Pathology on FacebookInstagram