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Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Message from the Vice Chair

"We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research 

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Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs via the descriptions below.

Affilated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Recent Publications

RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.

Song X, Tiek D, Miki S, Huang T, Lu M, Goenka A, Iglesia RP, Yu X, Wu R, Walker MN, Zeng C, Shah H, Weng SHS, Huff A, Zhang W, Koga T, Hubert CG, Horbinski CM, Furnari FF, Hu B, Cheng SY.

J Clin Invest. 2024 Apr 25:e173789. doi: 10.1172/JCI173789. Online ahead of print.

Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease.

Moe A, Rayasam A, Sauber G, Shah RK, Doherty A, Yuan CY, Szabo A, Moore Ii BM, Colonna M, Cui W, Romero J, Zamora AE, Hillard CJ, Drobyski WR.

J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205. Online ahead of print.

Rosacea Core Domain Set for Clinical Trials and Practice: A Consensus Statement.

Dirr MA, Ahmed A, Schlessinger DI, Haq M, Shi V, Koza E, Ma M, Christensen RE, Ibrahim SA, Schmitt J, Johannsen L, Asai Y, Baldwin HE, Berardesca E, Berman B, Vieira AC, Chien AL, Cohen DE, Del Rosso JQ, Dosal J, Drake LA, Feldman SR, Fleischer AB Jr, Friedman A, Graber E, Harper JC, Helfrich YR, Jemec GB, Johnson SM, Katta R, Lio P, Maier LE, Martin G, Nagler AR, Neuhaus IM, Palamar M, Parish LC, Rosen T, Shumack SP, Solomon JA, Tanghetti EA, Webster GF, Weinkle A, Weiss JS, Wladis EJ, Maher IA, Sobanko JF, Cartee TV, Cahn BA, Alam M; IMPROVED-COS Rosacea Working Group; Kang BY, Iyengar S, Anvery N, Alpsoy E, Bewley A, Dessinioti C, Egeberg A, Engin B, Gollnick HPM, Ioannides D, Kim HS, Lazaridou E, Li J, Lim HG, Micali G, de Oliveira CMM, Noguera-Morel L, Parodi A, Reinholz M, Suh DH, Sun Q, van Zuuren EJ, Wollina U, Zhou Y, Zip C, Poon E, Pearlman R.

JAMA Dermatol. 2024 Apr 24. doi: 10.1001/jamadermatol.2024.0636. Online ahead of print.

Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy.

Wang-Bishop L, Wehbe M, Pastora LE, Yang J, Kimmel BR, Garland KM, Becker KW, Carson CS, Roth EW, Gibson-Corley KN, Ulkoski D, Krishnamurthy V, Fedorova O, Richmond A, Pyle AM, Wilson JT.

ACS Nano. 2024 Apr 23. doi: 10.1021/acsnano.3c06225. Online ahead of print.

Defining and benchmarking open problems in single-cell analysis.

Luecken MD, Gigante S, Burkhardt DB, Cannoodt R, Strobl DC, Markov NS, Zappia L, Palla G, Lewis W, Dimitrov D, Vinyard ME, Magruder DS, Andersson A, Dann E, Qin Q, Otto DJ, Klein M, Botvinnik OB, Deconinck L, Waldrant K; Open Problems Jamboree Members; Bloom JM, Pisco AO, Saez-Rodriguez J, Wulsin D, Pinello L, Saeys Y, Theis FJ, Krishnaswamy S.

Res Sq [Preprint]. 2024 Apr 4:rs.3.rs-4181617. doi: 10.21203/rs.3.rs-4181617/v1.

In Vivo Mapping of Myocardial Injury Outside the Infarct Zone: Tissue at an Intermediate Pathological State.

Ren K, Hou S, Johnson SE, Lomasney J, Haney CR, Lee J, Ge ZD, Lee DC, Goldberger JJ, Arora R, Zhao M.

J Am Heart Assoc. 2024 Apr 19:e032577. doi: 10.1161/JAHA.123.032577. Online ahead of print.

The Silva pattern-based classification for HPV-associated endocervical adenocarcinoma: A single institution concordance study of trainees and gynecologic pathologists.

Felicelli C, Smith SH, Griffin B, Grubs A, Strom D, Shanes E, Strickland A, Purdy J, Novo JE, Wei JJ, Blanco LZ Jr.

Pathol Res Pract. 2024 Apr 16;257:155311. doi: 10.1016/j.prp.2024.155311. Online ahead of print.

Development and Validation of an 18-Gene Urine Test for High-Grade Prostate Cancer.

Tosoian JJ, Zhang Y, Xiao L, Xie C, Samora NL, Niknafs YS, Chopra Z, Siddiqui J, Zheng H, Herron G, Vaishampayan N, Robinson HS, Arivoli K, Trock BJ, Ross AE, Morgan TM, Palapattu GS, Salami SS, Kunju LP, Tomlins SA, Sokoll LJ, Chan DW, Srivastava S, Feng Z, Sanda MG, Zheng Y, Wei JT, Chinnaiyan AM; EDRN-PCA3 Study Group.

JAMA Oncol. 2024 Apr 18. doi: 10.1001/jamaoncol.2024.0455. Online ahead of print.

Estimating the serological underrecognition of patients with weak or partial RHD variants.

Ramsey G, Barriteau CM.

Transfusion. 2024 Apr 18. doi: 10.1111/trf.17810. Online ahead of print.

2-Step-Scores with optional nephropathology for the prediction of adverse outcomes for brain-dead donor kidneys in Eurotransplant.

Ernst A, Regele H, Chatzikyrkou C, Dendooven A, Turkevi-Nagy S, Tieken I, Oberbauer R, Reindl-Schwaighofer R, Abramowicz D, Hellemans R, Massart A, Ljubanovic DG, Senjug P, Maksimovic B, Aßfalg V, Neretljak I, Schleicher C, Clahsen-van Groningen M, Kojc N, Ellis CL, Kurschat CE, Lukomski L, Stippel D, Ströhlein M, Scurt FG, Roelofs JJ, Kers J, Harth A, Jungck C, Eccher A, Prütz I, Hellmich M, Vasuri F, Malvi D, Arns W, Becker JU.

Nephrol Dial Transplant. 2024 Apr 17:gfae093. doi: 10.1093/ndt/gfae093. Online ahead of print.

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