Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs via the descriptions below.

Affilated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Recent Publications

Integrity of neuronal size in the entorhinal cortex is a biologic substrate of exceptional cognitive aging.

Nassif C, Kawles A, Ayala I, Minogue G, Gill NP, Shepard RA, Zouridakis A, Keszycki R, Zhang H, Mao Q, Flanagan ME, Bigio EH, Mesulam MM, Rogalski E, Geula C, Gefen T.

J Neurosci. 2022 Sep 26:JN-RM-0679-22. doi: 10.1523/JNEUROSCI.0679-22.2022. Online ahead of print.

Role of Viscoelastic and Conventional Coagulation Tests for Management of Blood Product Replacement in the Bleeding Patient.

Matkovic E, Lindholm PF.

Semin Thromb Hemost. 2022 Sep 29. doi: 10.1055/s-0042-1756192. Online ahead of print.

Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness.

Grobbelaar LM, Kruger A, Venter C, Burger EM, Laubscher GJ, Maponga TG, Kotze MJ, Kwaan HC, Miller JB, Fulkerson D, Huff W, Chang E, Wiarda G, Bunch CM, Walsh MM, Raza S, Zamlut M, Moore HB, Moore EE, Neal MD, Kell DB, Pretorius E.

Semin Thromb Hemost. 2022 Sep 29. doi: 10.1055/s-0042-1756306. Online ahead of print.

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program.

Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, Lin JX, Hu B, West EE, Scharer CD, Freeman GJ, Sharpe AH, Ramalingam SS, Pellerin A, Teichgräber V, Greenleaf WJ, Klein C, Goronzy JJ, Umaña P, Leonard WJ, Smith KA, Ahmed R.

Nature. 2022 Sep 28. doi: 10.1038/s41586-022-05257-0. Online ahead of print.

Vancomycin-resistant Enterococcus (VRE) outbreak in a Pre- and Post-cardiothoracic transplant population: impact of discontinuing Multidrug-resistant organism (MDRO) Surveillance during the COVID-19 pandemic.

Rathod SN, Bardowski L, Tse I, Churyla A, Fiehler M, Malczynski M, Qi C, Tanna SD, Bulger C, Al-Qamari A, Oakley R, Zembower TR.

Transpl Infect Dis. 2022 Sep 28. doi: 10.1111/tid.13972. Online ahead of print.

Organotypic Human Skin Cultures Incorporating Primary Melanocytes.

Roth-Carter QR, Koetsier JL, Broussard JA, Green KJ.

Curr Protoc. 2022 Sep;2(9):e536. doi: 10.1002/cpz1.536.

Disease-Defining Molecular Features of Primary Cutaneous B-Cell Lymphomas: Implications for Classification and Treatment.

Zhang Y, LeWitt TM, Louissaint A Jr, Guitart J, Zhou XA, Choi J.

J Invest Dermatol. 2022 Sep 24:S0022-202X(22)01887-5. doi: 10.1016/j.jid.2022.07.027. Online ahead of print.

Hepatic Deletion of X-box Binding Protein 1 in Farnesoid X Receptor Null Mice Leads to Enhanced Liver Injury.

Liu X, Khalafalla M, Chung C, Gindin Y, Hubchak S, LeCuyer B, Kriegermeier A, Zhang D, Qiu W, Ding X, Fang D, Green R.

J Lipid Res. 2022 Sep 23:100289. doi: 10.1016/j.jlr.2022.100289. Online ahead of print.

Transcriptome changes in stages of non-alcoholic fatty liver disease.

Aljabban J, Rohr M, Syed S, Khorfan K, Borkowski V, Aljabban H, Segal M, Mukhtar M, Mohammed M, Panahiazar M, Hadley D, Spengler R, Spengler E.

World J Hepatol. 2022 Jul 27;14(7):1382-1397. doi: 10.4254/wjh.v14.i7.1382.

Temporal order of clinical and biomarker changes in familial frontotemporal dementia.

Staffaroni AM, Quintana M, Wendelberger B, Heuer HW, Russell LL, Cobigo Y, Wolf A, Goh SM, Petrucelli L, Gendron TF, Heller C, Clark AL, Taylor JC, Wise A, Ong E, Forsberg L, Brushaber D, Rojas JC, VandeVrede L, Ljubenkov P, Kramer J, Casaletto KB, Appleby B, Bordelon Y, Botha H, Dickerson BC, Domoto-Reilly K, Fields JA, Foroud T, Gavrilova R, Geschwind D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Hall MGH, Hsiung GY, Huey ED, Irwin D, Jones DT, Kantarci K, Kaufer D, Knopman D, Kremers W, Lago AL, Lapid MI, Litvan I, Lucente D, Mackenzie IR, Mendez MF, Mester C, Miller BL, Onyike CU, Rademakers R, Ramanan VK, Ramos EM, Rao M, Rascovsky K, Rankin KP, Roberson ED, Savica R, Tartaglia MC, Weintraub S, Wong B, Cash DM, Bouzigues A, Swift IJ, Peakman G, Bocchetta M, Todd EG, Convery RS, Rowe JB, Borroni B, Galimberti D, Tiraboschi P, Masellis M, Finger E, van Swieten JC, Seelaar H, Jiskoot LC, Sorbi S, Butler CR, Graff C, Gerhard A, Langheinrich T, Laforce R, Sanchez-Valle R, de Mendonça A, Moreno F, Synofzik M, Vandenberghe R, Ducharme S, Le Ber I, Levin J, Danek A, Otto M, Pasquier F, Santana I, Kornak J, Boeve BF, Rosen HJ, Rohrer JD, Boxer AL; Frontotemporal Dementia Prevention Initiative (FPI) Investigators.

Nat Med. 2022 Sep 22. doi: 10.1038/s41591-022-01942-9. Online ahead of print.

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