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Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department's investigations below.

We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research

Peng Ji, MD, PhD, headshot
Two women in a lab handling liquids

Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease to develop new and improved strategies to diagnose and treat inherited, acquired and infectious disorders. Learn more about the work being done in our labs.

Explore Our Research Areas

Affiliated Research Centers & Institutes

Our department faculty conduct research within the department and across Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrates the importance we place on scientific collaboration.

Research Cores

Core facilities provide cost-effective access to state-of-the-art equipment, the latest technologies and expert technical advice for individual scientists.

Pathology Core Facility

The Pathology Core Facility is a centralized, comprehensive laboratory providing histology, immunohistochemistry, molecular analysis, extraction and microscopic evaluation services for human tissue-based studies.

About Pathology Core Facility

Mouse Histology & Phenotyping Laboratory

The Mouse Histology & Phenotyping Laboratory (MHPL) assists primary investigators and scientists with standard and customized research-specific histology services.

About MHPL

Skin Biology and Diseases Resource-Based Center

The Skin Biology and Diseases Resource-Based Center (SBDRC) promotes outstanding bench and clinical research in cutaneous biology to improve patient care.

About SBDRC

Explore Recent Publications

Efineptakin alfa (NT-I7) improves overall survival and induces immune niches in murine tumors.

Dinh T, Lee J, Islam S, Nanda N, Bjelivuk D, Andrews D, Zhang J, Mani NL, Zhou J, Wolfarth AA

Genes Dis 2027 Jan;14(1):102136. pii:102136

Sirt1 transgene delivery improves diabetes-impaired wound healing.

Luo R, Wang H, Duan C, Jen M, Kuo HY, Wang X, Mrksich M, Ameer G

Bioact Mater 2026 Nov;65:521-534. doi:10.1016/j.bioactmat.2026.06.007

Therapy-associated lineage plasticity in DIPG following combined CDK4/6 inhibitor, temozolomide, and radiation.

Huang ZL, Jiang T, Suarez Palacios MM, Ouyang T, Abdallah A, Niu L, Chen J, Zhai X, Ciolak E, Qiang W

Cancer Lett 2026 Oct 28;659:218771. doi:10.1016/j.canlet.2026.218771

Switches in alternatively spliced isoforms impact protein and drug interactions in melanoma, ovarian cancer, and acute myeloid leukemia.

Karakulak T, , Moch H, von Mering C, Kahraman A

Br J Cancer 2026 Oct 03;. doi:10.1038/s41416-026-03638-0

A distinctive RhD serologic phenotype expressed by p.Glu233Lys RHD alleles DV type 5 and DAU4 in microplate agglutination RhD typing.

Karne V, Jedrzejczak MJ, Lindholm PF, Ramsey G, Hudgins JP

Transfusion 2026 Oct 02;. doi:10.1111/trf.70408

Prevalence of PD-L1-High Tumor Expression and Association with First-Line Treatment Outcomes in Patients with Metastatic Urothelial Carcinoma: Results from a Prospective Observational Cohort Study.

Grivas P, Agarwal PK, Al-Ahmadie H, Friedlander T, Geynisman DM, Lotan Y, Morgans AK, Bianco FJ, Chandana S, Fang B

Target Oncol 2026 Oct 02;. doi:10.1007/s11523-026-01257-6

Incorporating coaching in the moment and coaching over time to support entrustable professional activity-based assessment in pathology residency training.

Schiffhauer LM, Timmons CF, Henderson-Jackson E, Johnson K, McCloskey CB, Hébert TM, Brissette M, Gordezky R, Novo JE, Pagan C

Acad Pathol 2026;13(4):100298. pii:100298

An evidence-based workflow for integrating molecular testing with histopathology in the workup of meningiomas.

Congivaram H, Thirunavu V, Santana-Santos L, Jamshidi P, Arendhsen JT, Castellani RJ, Brat DJ, Cooper LAD, Ayad MA, Chen WC

Neuro Oncol 2026 Oct 01;. pii:noag217

High-grade astrocytoma with piloid features: A clinical and genomic analysis of prognostic factors using a large cohort.

Zhang S, Singh O, Dazelle K, Quezado M, Cimino PJ, Abdullaev Z, Wu J, Lucas CH, Schreck KC, Holdhoff M

Neuro Oncol 2026 Oct 01;28(10):2435-2448. doi:10.1093/neuonc/noag145

A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.

Virolainen SJ, Creighton K, Dashtiahangar M, Krishnamurthy D, Parks L, Forney C, Ampadu B, Rudrapatna AN, Dunn KA, Parameswaran S

Am J Hum Genet 2026 Oct 01;113(10):2118-2139. doi:10.1016/j.ajhg.2026.08.016

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