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Research

The Department of Pathology is deeply invested in scientific efforts to improve treatments in our field. Learn more about our department’s investigations below.

Message from the Vice Chair

"We are driven by a shared passion for discovery and a deep commitment to advancing human health through innovative research programs and collaborative partnerships among scientists and pathologists."

Peng Ji, MD, PhD
Vice Chair of Research 

Read Full Message

Areas of Research

Members of the Department of Pathology are defining the cellular and molecular basis of disease toward the development of new and improved strategies to diagnose and treat, inherited, acquired and infectious disorders. Learn more about the work being done in our labs.

Research Areas

Affiliated Research Centers and Institutes

The faculty members of Northwestern University Feinberg School of Medicine’s Department of Pathology are engaged in research within the department and throughout Northwestern Medicine and Northwestern University. Our work throughout the community, including director appointments, illustrate the importance we put on scientific collaboration.

Research Cores

Core facilities provide cost-efficient access of state-of-the-art equipment, the most current technologies and expert technical advice to individual scientists.

Learn more about our affiliated cores

Research Resources

Recent Publications

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells.

Siniscalco ER, Fisher C, Lu MP, Grassmann JDS, Mack CD, Yaakoubi R, Jacobsen D, Chen Q, Lee D, Rajamanimuthu P, Simoneau T, Preece K, Gray P, Okada S, Boisson B, Kayaoglu B, Danielson J, Freeman AF, Casanova JL, Chatila TA, Su HC, Ma CS, Williams A, Eisenbarth SC, Gowthaman U.

J Exp Med. 2026 Mar 2;223(3):e20241707. doi: 10.1084/jem.20241707. Epub 2026 Jan 28.

Artificial Intelligence and Machine Learning in Health Care: Current Capabilities, Emerging Potential, and Future Directions.

Liebovitz D, Wu A, Reamer C, Vadasz B.

Med Clin North Am. 2026 Mar;110(2):307-327. doi: 10.1016/j.mcna.2025.07.011. Epub 2025 Dec 1.

Circulating cell-free DNA methylation biomarkers for hepatocellular carcinoma risk prediction in HIV-positive Nigerian population.

Zheng Y, Han J, Qu Y, Wang J, Joyce BT, Okeke E, Davwar PM, Duguru MJ, Nyam DP, Odeghe E, Oyeleke G, Lesi OA, Imade GE, Sulaimon AA, Hawkins C, Abdulkareem FB, Badmos K, Gursel DB, Wei JJ, Silas OA, Kocherginsky M, Kim KA, Sun Z, Achenbach CJ, Zhang X, Yang H, Sagay AS, Ogunsola FT, Murphy RL, Roberts LR, Hou L.

Int J Cancer. 2026 Mar 1;158(5):1281-1291. doi: 10.1002/ijc.70204. Epub 2025 Oct 23.

Clinical trials and quasi-experimental studies in the treatment of noninfectious retinal vasculitis: A systematic review from the International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) - Report 4.

Saboya-Galindo P, Cifuentes-González C, Rojas-Carabali W, Mejía-Salgado G, Le Tong Y, Putera I, Song XYR, Walter CFY, Shengjuan Z, Chan R, La Distia Nora R, Biswas J, Gangaputra S, Pulido JS, Kempen JH, Nguyen QD, de-la-Torre A, Gupta V, Rosenbaum JT, Agrawal R; REVISE-IUSG study group.

Surv Ophthalmol. 2026 Mar-Apr;71(2):545-559. doi: 10.1016/j.survophthal.2025.09.013. Epub 2025 Sep 20.

Work-up in patients with retinal vasculitis: A systematic review and meta-analysis: International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Report 2.

Cifuentes-González C, Putera I, Walter CFY, Mejía-Salgado G, Le Tong Y, Chan R, Rojas-Carabali W, Song XYR, Mobasserian A, Nora RD, Biswas J, Gangaputra S, Pulido JS, Kempen JH, Nguyen QD, de-la-Torre A, Gupta V, Rosenbaum JT, Agrawal R; REVISE-IUSG study group.

Surv Ophthalmol. 2026 Mar-Apr;71(2):529-544. doi: 10.1016/j.survophthal.2025.09.011. Epub 2025 Sep 17.

Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection.

Niu H, Lin S, Brown R, Shen J, Kharel A, Zhang Y, Gai K, Bauer A, Brown A, Xu Z, Brooks DG, Cui W.

Proc Natl Acad Sci U S A. 2026 Feb 3;123(5):e2522928123. doi: 10.1073/pnas.2522928123. Epub 2026 Jan 30.

Agonistic GITR treatment enhances antitumor immune responses and suppresses tumor progression in pancreatic ductal adenocarcinoma.

Robatel S, Hillen H, Mutisheva I, Müller JC, Wartenberg M, Ma F, Bäriswyl L, Evenepoel J, Scheele CLGJ, Lee DJ, Modlin RL, Kessler U, Nobis M, Z'graggen K, Schenk M.

J Gastroenterol. 2026 Feb 1. doi: 10.1007/s00535-026-02347-y. Online ahead of print.

WHO classification of skin tumours: key updates in the fifth edition.

Goldman-Lévy G, Barnhill R, Bastian BC, Kempf W, Elder D, Gerami P, Grayson W, Kazakov D, Massi D, Messina J, de la Fouchardière A, Lazar AJ, Brenn T, Rous B, Field A, Gill A, Hodge JC, Khoury JD, Leite K, Sayed S, Tan PH, Elenitsas R, Calonje E, Duncan LM, Zhiyong L, Moch H, Singh R, Wijesinghe H, Cree I, Lokuhetty D.

Histopathology. 2026 Feb;88(3):555-568. doi: 10.1111/his.15562. Epub 2025 Nov 20.

Axenfeld-Rieger Syndrome: From Zebrafish Models to Clinical Outcomes.

Bohnsack BL, Williams AL, Jacobson A, Drackley A, Bolton E, Rossen JL.

Am J Ophthalmol. 2026 Feb;282:225-252. doi: 10.1016/j.ajo.2025.11.010. Epub 2025 Nov 14.

Pediatric-Type Follicular Lymphoma of the Conjunctiva: Shared Histologic and Molecular Features With the Nodal Counterpart.

Flaifel A, Alves de Castro JV, Gong S, Schafernak K, Cheng J, Nasir N, Davies-Hill T, Tyagi M, Xi L, Pittaluga S, Raffeld M, Jaffe ES.

Am J Surg Pathol. 2026 Feb 1;50(2):139-146. doi: 10.1097/PAS.0000000000002484. Epub 2025 Nov 13.

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